考拉内源性逆转录病毒的跨物种传播。
Transspecies transmission of the endogenous koala retrovirus.
作者信息
Fiebig Uwe, Hartmann Manuel Garcia, Bannert Norbert, Kurth Reinhard, Denner Joachim
机构信息
Robert Koch Institute, Nordufer 20, D-13353 Berlin, Germany.
出版信息
J Virol. 2006 Jun;80(11):5651-4. doi: 10.1128/JVI.02597-05.
Abstract
The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of rats in vivo, using immunological and PCR methods for virus detection. The KoRV transmembrane envelope protein (p15E) was cloned and expressed, and p15E-specific neutralizing antibodies able to prevent virus infection in vitro were developed. Finally, evidence for immunosuppressive properties of the KoRV was obtained.
摘要
考拉逆转录病毒（KoRV）是一种与长臂猿白血病病毒密切相关的γ逆转录病毒，可引发白血病以及与机会性感染（如衣原体病）相关的免疫缺陷。在此，我们对从德国一家动物园的一只动物身上新分离出的KoRV进行了特征描述，并使用免疫学和PCR方法检测病毒，展示了其在体外对人及大鼠细胞系的感染以及在体内对大鼠的感染。克隆并表达了KoRV跨膜包膜蛋白（p15E），并研制出了能够在体外预防病毒感染的p15E特异性中和抗体。最后，获得了KoRV具有免疫抑制特性的证据。
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