• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Transspecies transmission of the endogenous koala retrovirus.考拉内源性逆转录病毒的跨物种传播。
J Virol. 2006 Jun;80(11):5651-4. doi: 10.1128/JVI.02597-05.
2
In vitro characterization of a koala retrovirus.考拉逆转录病毒的体外特性研究
J Virol. 2006 Mar;80(6):3104-7. doi: 10.1128/JVI.80.6.3104-3107.2006.
3
Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV) and the Koala Retrovirus (KoRV).γ逆转录病毒的跨物种传播以及长臂猿白血病病毒（GaLV）和考拉逆转录病毒（KoRV）的起源
Viruses. 2016 Dec 20;8(12):336. doi: 10.3390/v8120336.
4
Koala Retroviruses: Evolution and Disease Dynamics.考拉逆转录病毒：进化与疾病动态。
Annu Rev Virol. 2015 Nov;2(1):119-34. doi: 10.1146/annurev-virology-100114-055056.
5
Koala retroviruses: characterization and impact on the life of koalas.树袋熊逆转录病毒：特征及其对树袋熊生活的影响。
Retrovirology. 2013 Oct 23;10:108. doi: 10.1186/1742-4690-10-108.
6
Coinfection with koala retrovirus subtypes A and B and its impact on captive koalas in Japanese zoos.考拉逆转录病毒亚型 A 和 B 的合并感染及其对日本动物园圈养考拉的影响。
Arch Virol. 2019 Nov;164(11):2735-2745. doi: 10.1007/s00705-019-04392-w. Epub 2019 Sep 5.
7
Koala retrovirus diversity, transmissibility, and disease associations.考拉逆转录病毒多样性、传染性和疾病关联。
Retrovirology. 2020 Oct 2;17(1):34. doi: 10.1186/s12977-020-00541-1.
8
Biology and evolution of the endogenous koala retrovirus.考拉内源性逆转录病毒的生物学与进化
Cell Mol Life Sci. 2008 Nov;65(21):3413-21. doi: 10.1007/s00018-008-8499-y.
9
Molecular Dynamics and Mode of Transmission of Koala Retrovirus as It Invades and Spreads through a Wild Queensland Koala Population.分子动力学与考拉逆转录病毒的传播模式，如其入侵和在昆士兰野生考拉种群中传播的方式。
J Virol. 2018 Mar 1;92(5). doi: 10.1128/JVI.01871-17. Epub 2017 Dec 13.
10
Transmission, Evolution, and Endogenization: Lessons Learned from Recent Retroviral Invasions.传播、进化和内源性化：从最近的逆转录病毒入侵中吸取的教训。
Microbiol Mol Biol Rev. 2017 Dec 13;82(1). doi: 10.1128/MMBR.00044-17. Print 2018 Mar.

引用本文的文献

1
The relationship between HERVs and exogenous viral infections: A focus on the value of HERVs in disease prediction and treatment.内源性逆转录病毒与外源病毒感染之间的关系：聚焦内源性逆转录病毒在疾病预测和治疗中的价值。
Virulence. 2025 Dec;16(1):2523888. doi: 10.1080/21505594.2025.2523888. Epub 2025 Jul 1.
2
How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs.如何检测猪器官移植患者中的猪内源性逆转录病毒（PERV）感染
Xenotransplantation. 2025 Jan-Feb;32(1):e70028. doi: 10.1111/xen.70028.
3
piRNA Defense Against Endogenous Retroviruses.piRNA对内源逆转录病毒的防御作用
Viruses. 2024 Nov 9;16(11):1756. doi: 10.3390/v16111756.
4
A novel multi-variate immunological approach, reveals immune variation associated with environmental conditions, and co-infection in the koala (Phascolarctos cinereus).一种新的多变量免疫方法揭示了与环境条件和考拉（Phascolarctos cinereus）共感染相关的免疫变异。
Sci Rep. 2024 Mar 27;14(1):7260. doi: 10.1038/s41598-024-57792-7.
5
Investigation of koala retrovirus in captive koalas with pneumonia and comparative analysis of subtype distribution.调查患有肺炎的圈养考拉中的考拉逆转录病毒，并比较分析亚型分布。
Arch Virol. 2023 Nov 27;168(12):298. doi: 10.1007/s00705-023-05928-x.
6
Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas.考拉逆转录病毒载量和非 A 亚型与野生北部考拉的继发疾病有关。
PLoS Pathog. 2022 May 19;18(5):e1010513. doi: 10.1371/journal.ppat.1010513. eCollection 2022 May.
7
Vaccination against the Koala Retrovirus (KoRV): Problems and Strategies.针对考拉逆转录病毒（KoRV）的疫苗接种：问题与策略。
Animals (Basel). 2021 Dec 14;11(12):3555. doi: 10.3390/ani11123555.
8
Koala retrovirus genetic diversity and transmission dynamics within captive koala populations.考拉逆转录病毒的遗传多样性及其在圈养考拉种群内的传播动态。
Proc Natl Acad Sci U S A. 2021 Sep 21;118(38). doi: 10.1073/pnas.2024021118.
9
Molecular Diagnosis of Koala Retrovirus (KoRV) in South Australian Koalas ().南澳大利亚树袋熊考拉逆转录病毒（KoRV）的分子诊断（）
Animals (Basel). 2021 May 20;11(5):1477. doi: 10.3390/ani11051477.
10
Toll-Like Receptor and Cytokine Responses to Infection with Endogenous and Exogenous Koala Retrovirus, and Vaccination as a Control Strategy.内源性和外源性考拉逆转录病毒感染的 Toll 样受体和细胞因子反应，以及疫苗接种作为控制策略。
Curr Issues Mol Biol. 2021 Apr 30;43(1):52-64. doi: 10.3390/cimb43010005.

本文引用的文献

1
In vitro characterization of a koala retrovirus.考拉逆转录病毒的体外特性研究
J Virol. 2006 Mar;80(6):3104-7. doi: 10.1128/JVI.80.6.3104-3107.2006.
2
Antibodies neutralizing feline leukaemia virus (FeLV) in cats immunized with the transmembrane envelope protein p15E.在用跨膜包膜蛋白p15E免疫的猫中中和猫白血病病毒（FeLV）的抗体。
Immunology. 2006 Feb;117(2):229-37. doi: 10.1111/j.1365-2567.2005.02291.x.
3
Neutralising antibodies against the transmembrane protein of feline leukaemia virus (FeLV).针对猫白血病病毒（FeLV）跨膜蛋白的中和抗体。
Vaccine. 2005 May 9;23(25):3341-8. doi: 10.1016/j.vaccine.2005.01.091.
4
Porcine endogenous retroviruses PERV-A and PERV-B infect neither mouse cells in vitro nor SCID mice in vivo.猪内源性逆转录病毒PERV - A和PERV - B在体外既不感染小鼠细胞，在体内也不感染重症联合免疫缺陷（SCID）小鼠。
Intervirology. 2005;48(2-3):167-73. doi: 10.1159/000081745.
5
Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas.用于检测考拉内源性逆转录病毒的实时逆转录聚合酶链反应揭示了考拉血浆病毒载量与肿瘤疾病之间的关联。
J Gen Virol. 2005 Mar;86(Pt 3):783-787. doi: 10.1099/vir.0.80547-0.
6
Identification of receptors for pig endogenous retrovirus.猪内源性逆转录病毒受体的鉴定。
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6759-64. doi: 10.1073/pnas.1138025100. Epub 2003 May 9.
7
Neutralizing antibodies against conserved domains of p15E of porcine endogenous retroviruses: basis for a vaccine for xenotransplantation?针对猪内源性逆转录病毒p15E保守结构域的中和抗体：异种移植疫苗的基础？
Virology. 2003 Mar 15;307(2):406-13. doi: 10.1016/s0042-6822(02)00140-x.
8
Molecular identification and antibody testing of Chlamydophila pneumoniae in a subgroup of patients with HIV-associated dementia complex. Preliminary results.
J Neuroimmunol. 2003 Mar;136(1-2):172-7. doi: 10.1016/s0165-5728(02)00469-1.
9
Productive infection of human primary cells and cell lines with porcine endogenous retroviruses.猪内源性逆转录病毒对人原代细胞和细胞系的有效感染。
Virology. 2001 Jul 5;285(2):177-80. doi: 10.1006/viro.2001.0934.
10
Sensitive and specific immunological detection methods for porcine endogenous retroviruses applicable to experimental and clinical xenotransplantation.适用于实验性和临床异种移植的猪内源性逆转录病毒的灵敏且特异的免疫检测方法。
Xenotransplantation. 2001 May;8(2):125-35.

考拉内源性逆转录病毒的跨物种传播。

Transspecies transmission of the endogenous koala retrovirus.

作者信息

Fiebig Uwe, Hartmann Manuel Garcia, Bannert Norbert, Kurth Reinhard, Denner Joachim

机构信息

Robert Koch Institute, Nordufer 20, D-13353 Berlin, Germany.

出版信息

J Virol. 2006 Jun;80(11):5651-4. doi: 10.1128/JVI.02597-05.

DOI:10.1128/JVI.02597-05
PMID:16699047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1472152/
Abstract

The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of rats in vivo, using immunological and PCR methods for virus detection. The KoRV transmembrane envelope protein (p15E) was cloned and expressed, and p15E-specific neutralizing antibodies able to prevent virus infection in vitro were developed. Finally, evidence for immunosuppressive properties of the KoRV was obtained.

摘要

考拉逆转录病毒（KoRV）是一种与长臂猿白血病病毒密切相关的γ逆转录病毒，可引发白血病以及与机会性感染（如衣原体病）相关的免疫缺陷。在此，我们对从德国一家动物园的一只动物身上新分离出的KoRV进行了特征描述，并使用免疫学和PCR方法检测病毒，展示了其在体外对人及大鼠细胞系的感染以及在体内对大鼠的感染。克隆并表达了KoRV跨膜包膜蛋白（p15E），并研制出了能够在体外预防病毒感染的p15E特异性中和抗体。最后，获得了KoRV具有免疫抑制特性的证据。