Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Qingdao Center for Disease Control and Prevention, Qingdao, China.
J Intern Med. 2019 Sep;286(3):299-308. doi: 10.1111/joim.12926. Epub 2019 Jul 4.
The Chinese National Twin Registry (CNTR) currently includes data from 61 566 twin pair from 11 provinces or cities in China. Of these, 31 705, 15 060 and 13 531 pairs are monozygotic, same-sex dizygotic and opposite-sex dizygotic pairs, respectively, determined by opposite sex or intrapair similarity. Since its establishment in 2001, the CNTR has provided an important resource for analysing genetic and environmental influences on chronic diseases especially cardiovascular diseases. Recently, the CNTR has focused on collecting biologic specimens from disease-concordant or disease-discordant twin pairs or from twin pairs reared apart. More than 8000 pairs of these twins have been registered, and blood samples have been collected from more than 1500 pairs. In this review, we summarize the main findings from univariate and multivariate genetic effects analyses, gene-environment interaction studies, omics studies exploring DNA methylation and metabolomic markers associated with phenotypes. There remains further scope for CNTR research and data mining. The plan for future development of the CNTR is described. The CNTR welcomes worldwide collaboration.
中国国家双胞胎登记处（CNTR）目前包含来自中国 11 个省或直辖市的 61566 对双胞胎的数据。其中，31705 对、15060 对和 13531 对分别为同卵双生、同性异卵双生和异性异卵双生双胞胎，通过异性或同胞间相似性来确定。自 2001 年成立以来，CNTR 为分析遗传和环境对慢性疾病（尤其是心血管疾病）的影响提供了重要资源。最近，CNTR 专注于从疾病一致或疾病不一致的双胞胎或分开抚养的双胞胎中收集生物样本。已经有超过 8000 对双胞胎进行了登记，并且已经从超过 1500 对双胞胎中采集了血液样本。在这篇综述中，我们总结了从单变量和多变量遗传效应分析、基因-环境相互作用研究、探索与表型相关的 DNA 甲基化和代谢组学标记的组学研究中得出的主要发现。CNTR 研究和数据挖掘还有进一步的空间。描述了 CNTR 的未来发展计划。CNTR 欢迎全球合作。
