Bamini Lavanya, Anand Sherwood I, Abbott Paul V, Uthandakalaipandian Ramesh, Velu Vijay
Department of Conservative Dentistry and Endodontics, CSI College of Dental Sciences, Madurai, India.
University of Western Australia, Perth, Western Australia, Australia.
Aust Endod J. 2020 Apr;46(1):73-81. doi: 10.1111/aej.12353. Epub 2019 Jul 3.
One of the main objectives of root canal treatment is to alleviate the pain associated with irreversibly inflamed pulps. However, some patients may have moderate to severe pain following treatment. The aim of this study was to compare and assess the effect of ketorolac tromethamine on substance P expression in the pulp and periapical tissues when used as a root canal irrigant for single-visit root canal treatment in teeth with irreversible pulpitis. Thirty-six patients were randomly allotted to three irrigant groups - saline (n = 14), 3% sodium hypochlorite (n = 11) and ketorolac tromethamine (n = 11). Pulp blood samples (S1) were collected on gaining access to the pulp, and periapical blood samples (S2) were collected after root canal preparation. Quantification of substance P was done by ELISA test. The ketorolac tromethamine group had greater reduction in substance P expression (S2). Post-operative pain levels were not significantly influenced by the different root canal irrigants.
根管治疗的主要目标之一是缓解与不可逆性牙髓炎相关的疼痛。然而，一些患者在治疗后可能会出现中度至重度疼痛。本研究的目的是比较和评估酮咯酸氨丁三醇作为根管冲洗剂用于不可逆性牙髓炎患牙的一次性根管治疗时，对牙髓和根尖周组织中P物质表达的影响。36例患者被随机分为三组冲洗剂组——生理盐水组（n = 14）、3%次氯酸钠组（n = 11）和酮咯酸氨丁三醇组（n = 11）。在进入牙髓时采集牙髓血样本（S1），根管预备后采集根尖周血样本（S2）。通过ELISA试验对P物质进行定量分析。酮咯酸氨丁三醇组P物质表达（S2）的降低幅度更大。不同的根管冲洗剂对术后疼痛水平没有显著影响。
