Evangelin J, Sherwood I Anand, Abbott Paul V, Uthandakalaipandian Ramesh, Velu Vijay
Department of Conservative Dentistry and Endodontics, CSI College of Dental Sciences, Madurai, Tamil Nadu, India.
UWA Dental School, The University of Western Australia, Perth, Australia.
Aust Endod J. 2020 Apr;46(1):17-25. doi: 10.1111/aej.12340. Epub 2019 Jul 3.
The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3% sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL-8 were done using ELISA test. Post-operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values. Dexamethasone irrigation was more effective in controlling post-operative pain.
本研究的目的是评估酮咯酸氨丁三醇和地塞米松作为急性不可逆性牙髓炎单次就诊根管治疗的根管冲洗剂时，对P物质和白细胞介素-8表达的影响。本研究共纳入42例因龋损前磨牙和磨牙导致急性不可逆性牙髓炎疼痛的患者。四个冲洗组如下：生理盐水组（n = 11）、3%次氯酸钠组（n = 11）、酮咯酸氨丁三醇组（n = 10）和地塞米松组（n = 10）。分别在开髓时和根管预备后采集血样S1和S2。使用酶联免疫吸附测定（ELISA）试验对P物质和白细胞介素-8进行定量分析。通过询问患者评估术后疼痛情况。四个不同冲洗剂组的S1和S2样本值之间的差异无统计学意义。次氯酸钠组的P物质和白细胞介素-8值的平均表达较高。地塞米松冲洗在控制术后疼痛方面更有效。
