淋巴细胞因子诱导培养的视网膜色素上皮细胞上的MHC II类抗原表达及环孢素A的影响。
Lymphokine-induced MHC class II antigen expression on cultured retinal pigment epithelial cells and the influence of cyclosporin A.
作者信息
Liversidge J, Sewell H F, Thomson A W, Forrester J V
机构信息
Department of Ophthalmology, University of Aberdeen, U.K.
出版信息
Immunology. 1988 Feb;63(2):313-7.
Culture of rat or guinea-pig retinal pigment epithelium (RPE) cells with Con A-induced lymphokine derived from splenic lymphocytes or rat recombinant IFN-gamma induces strong MHC class II (Ia) antigen expression on up to 40% of RPE cells. Cyclosporin A, which inhibits intravitreal inflammation and Ia antigen expression on RPE cells in vivo, despite a choroidal T-cell infiltrate, suppresses production of Ia-inducing lymphokine but does not suppress in vitro responses of RPE cells to preformed lymphokine.
用来自脾淋巴细胞的伴刀豆球蛋白A诱导的淋巴因子或大鼠重组干扰素-γ培养大鼠或豚鼠视网膜色素上皮（RPE）细胞，可诱导高达40%的RPE细胞强烈表达MHC II类（Ia）抗原。环孢素A可抑制玻璃体内炎症以及体内RPE细胞上Ia抗原的表达，尽管脉络膜有T细胞浸润，它能抑制Ia诱导性淋巴因子的产生，但不抑制RPE细胞对预先形成的淋巴因子的体外反应。
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