Detrick B, Newsome D A, Percopo C M, Hooks J J
Clin Immunol Immunopathol. 1985 Aug;36(2):201-11. doi: 10.1016/0090-1229(85)90121-7.
Monocytes from retinitis pigmentosa patients express diminished amounts of class II (HLA-DR) antigens in comparison to normal individuals, normal siblings of retinitis pigmentosa patients, glaucoma patients, and macular degeneration patients. This observation is correlated with a subnormal production of IFN-gamma, a potent regulator of class II antigen expression. When monocytes from retinitis pigmentosa patients are treated with IFN-gamma, the decreased expression of HLA-DR on the cell surface is restored to levels found on monocytes from normal individuals. HLA-DR antigens were detected on the surfaces of human retinal pigment epithelial cells grown in vitro and the expression of these antigens can be enhanced following IFN-gamma treatment. These data demonstrate an altered expression and regulation of class II, HLA-DR, antigens in a human eye disease. Since class II antigens and IFN-gamma are currently known to be necessary regulating proteins for efficient immune reactivity, these findings may indicate an immune disturbance in retinitis pigmentosa patients. Alternatively, this alteration may have nonimmune implications. For example, these studies may demonstrate an imbalance in systemic regulatory control systems and hence raise the possibility that these or related regulatory proteins and cell surface receptors may be instrumental in maintaining retinal integrity.
与正常个体、视网膜色素变性患者的正常同胞、青光眼患者及黄斑变性患者相比，视网膜色素变性患者的单核细胞表达的II类（HLA-DR）抗原量减少。这一观察结果与II类抗原表达的强效调节因子γ干扰素的产生低于正常水平相关。用γ干扰素处理视网膜色素变性患者的单核细胞后，细胞表面HLA-DR表达的降低可恢复至正常个体单核细胞的水平。在体外培养的人视网膜色素上皮细胞表面检测到了HLA-DR抗原，γ干扰素处理后这些抗原的表达可增强。这些数据表明，在一种人类眼病中，II类HLA-DR抗原的表达和调节发生了改变。由于目前已知II类抗原和γ干扰素是有效免疫反应所必需的调节蛋白，这些发现可能表明视网膜色素变性患者存在免疫紊乱。或者，这种改变可能具有非免疫方面的影响。例如，这些研究可能表明全身调节控制系统失衡，因此增加了这些或相关调节蛋白及细胞表面受体可能有助于维持视网膜完整性的可能性。
