Guo Lei, Xu Chen, Wu Ding-Chuan, Hu Guang-Qi, Zhang Hong-Hai, Hong Kunlun, Chen Su, Liu Xiang
College of Chemistry and Chemical Engineering, Nanjing Tech. University (Nanjing Tech.), 30 Puzhu Road, Nanjing 211816, P. R. China.
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing Tech. University (Nanjing Tech.), 30 Puzhu Road, Nanjing 211816, P. R. China.
Chem Commun (Camb). 2019 Jul 18;55(59):8567-8570. doi: 10.1039/c9cc03988k.
An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.
已公开了一种通过与芳基碘进行级联烷基化和氘代反应来合成稠合氘标记芳烃的有效方法。我们发现，采用甲酸钠-d作为氘源是实现>98%的高氘掺入率的关键。
