Department of Internal Medicine, Ege University Hospital, 35030, Izmir, Turkey.
Division of Hematology, Ege University Hospital, Izmir, Turkey.
Support Care Cancer. 2020 Mar;28(3):1441-1448. doi: 10.1007/s00520-019-04952-5. Epub 2019 Jul 4.
The aim of this study was to assess the association between malnutrition status with the (Global Leadership Initiative on Malnutrition) GLIM criteria and 1-year mortality in hospitalized patients with hematologic malignancy.
This study included 120 hospitalized patients with hematologic malignancy. Patients who were at risk of malnutrition with NRS2002 were reevaluated with the GLIM criteria for defined malnutrition. Also, the mid-upper arm circumference (MUAC), calf circumference (CC), and handgrip (HG) were measured, and albumin, C reactive protein (CRP), and total protein were recorded to assess malnutrition-related factors.
A total of 120 patients are with lymphoma, leukemia, and myeloma having a rate of 34.2%, 34.2%, and 31.6%, respectively, and risk of malnutrition with NRS2002 was established in 82% of patients. Malnutrition with GLIM criteria was seen in 25.8% of patients. The 1-year mortality rate was 41.7% (n = 50). Malnutrition was associated with higher mortality risk independently with age and duration of diagnosis (HR 3.55 (1.99-6.34), p = 0.001). Low HG (HR 0.51 (0.26-0.99), p = 0.03), low albumin (HR 0.39 (0.2-0.6), p = 0.001), and high CRP (HR 2.39 (1.36-4.20), p = 0.002) were significantly associated with increased mortality risk. In contrast, BMI, MUAC, FFMI, and CC were not associated with higher mortality.
Malnutrition is high with the GLIM criteria. Hospitalized patients with hematologic malignancy with malnutrition have a higher 1-year mortality risk.
本研究旨在评估营养不良状况与（全球营养不良倡议）GLIM 标准的相关性，并评估其与血液病住院患者 1 年死亡率的关系。
本研究纳入了 120 例血液病住院患者。有营养不良风险的 NRS2002 患者，根据 GLIM 标准重新评估为明确的营养不良。同时测量上臂中部周长（MUAC）、小腿周长（CC）和握力（HG），并记录白蛋白、C 反应蛋白（CRP）和总蛋白，以评估与营养不良相关的因素。
共 120 例患者分别为淋巴瘤、白血病和骨髓瘤，发生率分别为 34.2%、34.2%和 31.6%，82%的患者存在 NRS2002 营养不良风险。根据 GLIM 标准，25.8%的患者存在营养不良。1 年死亡率为 41.7%（n=50）。营养不良与较高的死亡风险独立相关，与年龄和诊断持续时间有关（HR 3.55（1.99-6.34），p=0.001）。低 HG（HR 0.51（0.26-0.99），p=0.03）、低白蛋白（HR 0.39（0.2-0.6），p=0.001）和高 CRP（HR 2.39（1.36-4.20），p=0.002）与死亡风险增加显著相关。相反，BMI、MUAC、FFMI 和 CC 与较高的死亡率无关。
根据 GLIM 标准，营养不良的发生率较高。患有血液病且营养不良的住院患者 1 年死亡率较高。
