老年营养风险指数不是弥漫性大 B 细胞淋巴瘤患者的独立预测指标。
Geriatric nutritional risk index is not an independent predictor in patients with diffuse large B-cell lymphoma.
机构信息
The Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
The Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
出版信息
Cancer Biomark. 2018;21(4):813-820. doi: 10.3233/CBM-170754.
BACKGROUND
The prognostic value of geriatric nutritional risk index (GNRI) for diffuse large B-cell lymphoma (DLBCL) treated in the rituximab era was not clear.
OBJECTIVE
To investigate the prognostic impact of GNRI in patients with DLBCL in our hospital.
METHODS
DLBCL patients were recruited and classified into two groups with and without malnutrition based on GNRI. Clinical features, concentration of T-helper cell type (Th1/Th2/Th17) cytokine profiles and overall survival were compared between these two groups.
RESULTS
One hundred and five (39%) out of 267 patients were classified into malnutrition group. Patients with malnutrition had lower levels of albumin and hemoglobin, but older age, higher lactate dehydroxygenase (LDH) level, higher frequencies of advanced stage, poor performance status, B symptoms and extranodal involvement, higher scores of NCCN-IPI and higher level of INF-γ. Moreover, patients with malnutrition had poor overall survival in univariate analyses. But these significances did not stand after stratified analyses by NCCN-IPI, or in the context of NCCN-IPI in the multivariate analyses.
CONCLUSIONS
GNRI is not an independent predictor for DLBCL patients.
背景
在利妥昔单抗时代，老年营养风险指数（GNRI）对弥漫性大 B 细胞淋巴瘤（DLBCL）的预后价值尚不清楚。
目的
探讨 GNRI 在我院 DLBCL 患者中的预后影响。
方法
招募 DLBCL 患者，并根据 GNRI 将其分为有和无营养不良两组。比较两组之间的临床特征、辅助性 T 细胞（Th1/Th2/Th17）细胞因子谱的浓度和总生存率。
结果
267 例患者中有 105 例（39%）被归入营养不良组。营养不良患者的白蛋白和血红蛋白水平较低，但年龄较大、乳酸脱氢酶（LDH）水平较高、晚期阶段、较差的表现状态、B 症状和结外侵犯的频率较高、NCCN-IPI 评分较高、INF-γ 水平较高。此外，在单因素分析中，营养不良患者的总生存率较差。但是，在 NCCN-IPI 分层分析或 NCCN-IPI 多因素分析中，这些差异并不显著。
结论
GNRI 不是 DLBCL 患者的独立预后因素。
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