Amato M, Schaad U B
Division of Perinatology, University of Berne, Switzerland.
Helv Paediatr Acta. 1987;42(4):297-303.
Ceftazidime, a new cephalosporin antibiotic, was used as monotherapy to treat 75 term neonates with suspected perinatal bacterial infection. Septicemia was documented in ten patients (13%). Ceftazidime was administered as 25 mg/kg doses intravenously every 12 h. Peak serum concentrations at 0.5 h after dose ranged from 57 to 115 micrograms/ml and trough serum concentrations prior to next dose from 2 to 15 micrograms/ml. The overall clinical, bacteriological and laboratory response to ceftazidime was satisfactory and the drug was well tolerated. However, reservations with regard to study design, limited gram-positive drug activity and potential emergence of drug resistance require further well-controlled clinical evaluations of ceftazidime in neonatal intensive care units, before definite recommendations for the use of this antibiotic in perinatal infection can be formulated.
头孢他啶是一种新型头孢菌素抗生素，被用作单一疗法治疗75例有围生期细菌感染疑似症状的足月儿。10名患者（13%）被确诊为败血症。头孢他啶以每12小时25毫克/千克的剂量静脉注射给药。给药后0.5小时的血清峰值浓度范围为57至115微克/毫升，下次给药前的血清谷浓度为2至15微克/毫升。头孢他啶在总体临床、细菌学和实验室方面的反应令人满意，且药物耐受性良好。然而，鉴于研究设计、革兰氏阳性菌药物活性有限以及可能出现耐药性等问题，在能够制定出关于在围生期感染中使用这种抗生素的确切建议之前，需要在新生儿重症监护病房对头孢他啶进行进一步严格控制的临床评估。
