Medical Faculty and University Hospital, Center of Prevention and Rehabilitation, UniReha, University of Cologne, Cologne, Germany.
Department of Pediatrics, Medical Faculty and University Hospital, University of Cologne, Cologne, Germany.
Child Obes. 2019 Oct;15(7):476-484. doi: 10.1089/chi.2019.0122. Epub 2019 Jul 8.
Obesity was often associated with low high-density lipoprotein (HDL) cholesterol concentration, which is an established cardiovascular risk factor. To evaluate the association of HDL-cholesterol concentration with fat and muscle mass in children and adolescents. Data of the National Health and Nutrition Examination Survey (1999-2004) were used to estimate fat and muscle mass by dual-energy X-ray absorptiometry (DXA) of the participants who had also an examination of their lipid profiles. Fat mass was assessed by DXA-determined fat mass index (FMI). Muscle mass was operationalized by appendicular lean mass index (LMI). Low HDL-cholesterol concentration was defined as <40 mg/dL. For the evaluation of the association of HDL-cholesterol concentration with FMI and LMI Z-scores, the data of 6288 children and adolescents (age 8-19 years) (2535 females) were eligible. In the study population, the prevalence of low HDL-cholesterol concentration increased with rising FMI and appendicular LMI Z-scores. The study results suggested that there is a counterintuitive, inverse association of muscle mass and HDL-cholesterol concentration.
肥胖通常与低高密度脂蛋白（HDL）胆固醇浓度有关，而后者是已确定的心血管风险因素。本研究旨在评估儿童和青少年的高密度脂蛋白胆固醇浓度与脂肪和肌肉质量之间的关系。本研究使用 1999-2004 年全国健康和营养检查调查（NHANES）的数据，通过双能 X 射线吸收法（DXA）对参与者进行检测，以评估其血脂状况。脂肪质量通过 DXA 确定的脂肪质量指数（FMI）进行评估。肌肉质量通过四肢瘦体重指数（LMI）来操作化。低 HDL 胆固醇浓度定义为<40mg/dL。为了评估 HDL 胆固醇浓度与 FMI 和 LMI Z 评分之间的关联，本研究纳入了 6288 名 8-19 岁（2535 名女性）的儿童和青少年的数据。在研究人群中，随着 FMI 和四肢 LMI Z 评分的升高，低 HDL 胆固醇浓度的患病率也随之增加。研究结果表明，肌肉质量与 HDL 胆固醇浓度之间存在一种反直觉的、相反的关联。
