Martakis Kyriakos, Stark Christina, Rehberg Mirko, Jackels Miriam, Schoenau Eckhard, Duran Ibrahim
Center of Prevention and Rehabilitation - UniReha, University of Cologne, Medical Faculty and University Hospital, Cologne, Germany.
Department of Pediatrics, University of Cologne, Medical Faculty and University Hospital, Cologne, Germany.
J Pediatr Endocrinol Metab. 2021 Jul 19;34(10):1273-1282. doi: 10.1515/jpem-2021-0254. Print 2021 Oct 26.
Obesity has often been associated with high low-density-lipoprotein cholesterol (LDL-C) and triglyceride plasma concentrations, known risk factors for diabetes mellitus and cardiovascular disease. Study objective was to evaluate the association of LDL-C and triglyceride plasma concentration with muscle and fat mass in children and adolescents.
We analyzed data of the National Health and Nutrition Examination Survey (1999-2004) to estimate lean muscle and fat mass assessed by dual-energy X-ray absorptiometry (DXA) of participants whose lipid profiles had been examined. Fat mass was operationalized by DXA-determined fat mass index (FMI). Muscle mass was assessed by appendicular lean mass index (aLMI). High LDL-C and triglyceride concentration was defined as above 130 mg/dL.
For the evaluation of the association of LDL-C and triglyceride plasma concentration with LMI and FMI Z-scores, the data of 2,487 children and adolescents (age 8-19 years) (984 females) were eligible. High aLMI showed no association with LDL-C or triglyceride concentration, but high FMI showed significant association with LDL-C and triglyceride plasma concentration in the bivariate regression analysis.
Isolated muscle mass increase may not be protective against high LDL-C and triglycerides plasma levels in children and adolescents. Thus, exercise may lead to risk factor reduction mainly through fat mass reduction.
肥胖常与低密度脂蛋白胆固醇（LDL-C）升高及血浆甘油三酯浓度升高相关，而这两者是糖尿病和心血管疾病的已知危险因素。本研究的目的是评估儿童和青少年血浆LDL-C和甘油三酯浓度与肌肉量和脂肪量之间的关联。
我们分析了国家健康与营养检查调查（1999 - 2004年）的数据，以估计接受过血脂检查的参与者通过双能X线吸收法（DXA）评估的瘦肌肉量和脂肪量。脂肪量通过DXA测定的脂肪量指数（FMI）来衡量。肌肉量通过上肢瘦肌肉量指数（aLMI）进行评估。高LDL-C和甘油三酯浓度定义为高于130 mg/dL。
为评估血浆LDL-C和甘油三酯浓度与LMI和FMI Z评分之间的关联，2487名儿童和青少年（8 - 19岁）（984名女性）的数据符合要求。在双变量回归分析中，高aLMI与LDL-C或甘油三酯浓度无关联，但高FMI与血浆LDL-C和甘油三酯浓度存在显著关联。
单纯的肌肉量增加可能无法预防儿童和青少年的高LDL-C和高甘油三酯血浆水平。因此，运动可能主要通过减少脂肪量来降低危险因素。
