循环 miR-574-5p 水平与女性心搏骤停后神经功能结局相关：目标温度管理（TTM）试验的亚研究。
Circulating Levels of miR-574-5p Are Associated with Neurological Outcome after Cardiac Arrest in Women: A Target Temperature Management (TTM) Trial Substudy.
机构信息
Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen L-1445, Luxembourg.
Department of Cardiology, Clinical Sciences, Lund University and Skane University Hospital, Lund SE-221 85, Sweden.
出版信息
Dis Markers. 2019 Jun 2;2019:1802879. doi: 10.1155/2019/1802879. eCollection 2019.
PURPOSE
Postresuscitation neuroprognostication is guided by neurophysiological tests, biomarker measurement, and clinical examination. Recent investigations suggest that circulating microRNAs (miRNA) may help in outcome prediction after cardiac arrest. We assessed the ability of miR-574-5p to predict neurological outcome after cardiac arrest, in a sex-specific manner.
METHODS
In this substudy of the Target Temperature Management (TTM) Trial, we enrolled 590 cardiac arrest patients for which blood samples were available. Expression levels of miR-574-5p were measured by quantitative PCR in plasma samples collected 48 h after cardiac arrest. The endpoint of the study was poor neurological outcome at 6 months (cerebral performance category scores 3 to 5).
RESULTS
Eighty-one percent of patients were men, and 49% had a poor neurological outcome. Circulating levels of miR-574-5p at 48 h were higher in patients with a poor neurological outcome at 6 months ( < 0.001), both in women and in men. Circulating levels of miR-574-5p were univariate predictors of neurological outcome (odds ratio (OR) [95% confidence interval (CI)]: 1.5 [1.26-1.78]). After adjustment with clinical variables and NSE, circulating levels of miR-574-5p predicted neurological outcome in women (OR [95% CI]: 1.9 [1.09-3.45]), but not in men (OR [95% CI]: 1.0 [0.74-1.28]).
CONCLUSION
miR-574-5p is associated with neurological outcome after cardiac arrest in women.
目的
复苏后神经预后由神经生理测试、生物标志物测量和临床检查指导。最近的研究表明，循环 microRNAs (miRNA) 可能有助于预测心脏骤停后的预后。我们评估了 miR-574-5p 以性别特异性方式预测心脏骤停后神经结局的能力。
方法
在 Target Temperature Management (TTM) 试验的这项子研究中，我们纳入了 590 名可获得血液样本的心脏骤停患者。在心脏骤停后 48 小时采集的血浆样本中通过定量 PCR 测量 miR-574-5p 的表达水平。研究的终点是 6 个月时的不良神经结局（脑功能状态评分 3 至 5）。
结果
81%的患者为男性，49%有不良神经结局。6 个月时神经结局不良的患者（<0.001），女性和男性患者 48 小时时的 miR-574-5p 循环水平均较高。miR-574-5p 循环水平是神经结局的单变量预测因子（优势比[95%置信区间]：1.5[1.26-1.78]）。在与临床变量和 NSE 调整后，miR-574-5p 循环水平在女性中预测了神经结局（OR[95%CI]：1.9[1.09-3.45]），但在男性中没有（OR[95%CI]：1.0[0.74-1.28]）。
结论
miR-574-5p 与女性心脏骤停后神经结局相关。
Zotero 插件