Zinkernagel R M
Hosp Pract. 1978 Jul;13(7):83-92. doi: 10.1080/21548331.1978.11707372.
There is increasing support for the concept that in all of their varied immunologic functions, T lymphocytes act through a dual specificity. In the case of intracellular viral infections, the recognition required for cytolysis involves both a "self" component, coded for by the genes that specify the major transplantation antigens, and an "X" component, provided by viral antigens expressed on the target-cell surface.
