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Dietary Cholesterol, Serum Lipids, and Heart Disease: Are Eggs Working for or Against You?饮食中的胆固醇、血清脂质与心脏病：鸡蛋到底对你有益还是有害？
Nutrients. 2018 Mar 29;10(4):426. doi: 10.3390/nu10040426.
3
Intake of 3 Eggs per Day When Compared to a Choline Bitartrate Supplement, Downregulates Cholesterol Synthesis without Changing the LDL/HDL Ratio.每天摄入 3 个鸡蛋与服用酒石酸氢胆碱补充剂相比，可下调胆固醇合成而不改变 LDL/HDL 比值。
Nutrients. 2018 Feb 24;10(2):258. doi: 10.3390/nu10020258.
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Fatty acids modulate the expression levels of key proteins for cholesterol absorption in Caco-2 monolayer.脂肪酸调节 Caco-2 单层细胞中胆固醇吸收关键蛋白的表达水平。
Lipids Health Dis. 2018 Feb 20;17(1):32. doi: 10.1186/s12944-018-0675-y.
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Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study.超重人群内脏脂肪面积增加与血浆脂肪酸谱改变的相关性：一项横断面研究。
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Can J Diabetes. 2017 Aug;41(4):453-463. doi: 10.1016/j.jcjd.2016.12.002. Epub 2017 Mar 27.
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Nutrients. 2017 Jan 29;9(2):89. doi: 10.3390/nu9020089.
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正常饮食和高脂饮食条件下食用蛋黄对小鼠脂质代谢和脂肪酸谱的长期影响比较。

Comparison of long-term effects of egg yolk consumption under normal and high fat diet on lipid metabolism and fatty acids profile in mice.

作者信息

Yu Zhihui, Wang Ning, Hu Gan, Ma Meihu

机构信息

National R&D Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070 Hubei People's Republic of China.

出版信息

Food Sci Biotechnol. 2019 Jan 23;28(4):1195-1206. doi: 10.1007/s10068-018-00545-w. eCollection 2019 Aug.

DOI:10.1007/s10068-018-00545-w
PMID:31275720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6595090/
Abstract

This study compared the long-term effects of EY consumption under two diet conditions: normal (ND + EY) and high fat diet (HFD + EY), on lipid metabolism in mice. ND + EY did not increase serum triglycerides, total cholesterol hepatic triglyceride concentrations, adipose tissue accumulation and glucose impairment, not leading to fatty liver. HFD + EY markedly decreased adipose tissue accumulation, the triglyceride and total cholesterol, and improved serum HDL-C and blood glucose impairment compared with HFD. PLS-DA analyzes showed both ND + EY and HFD + EY could decrease serum C18:1 and MUFA. HFD + EY could further decrease hepatic C18:2 and PUFA and increase C18:1 and MUFA excretion, which were associated with lower expression of Elovl6 and higher expression of Scd1 in liver. These results suggest that HFD + EY significantly improved dyslipidemia caused by HFD through modifying lipid metabolism, and ND + EY did not adversely affect the biomarkers associated with dyslipidemia risk, but showed less obvious regulation of lipid metabolism than HFD + EY.

摘要

本研究比较了在两种饮食条件下（正常饮食（ND + EY）和高脂饮食（HFD + EY））食用EY对小鼠脂质代谢的长期影响。ND + EY不会增加血清甘油三酯、总胆固醇、肝脏甘油三酯浓度、脂肪组织堆积和葡萄糖损伤，不会导致脂肪肝。与HFD相比，HFD + EY显著减少了脂肪组织堆积、甘油三酯和总胆固醇，并改善了血清高密度脂蛋白胆固醇（HDL-C）和血糖损伤。偏最小二乘法判别分析（PLS-DA）显示，ND + EY和HFD + EY均可降低血清C18:1和单不饱和脂肪酸（MUFA）。HFD + EY可进一步降低肝脏C18:2和多不饱和脂肪酸（PUFA），并增加C18:1和MUFA的排泄，这与肝脏中脂肪酸延长酶6（Elovl6）表达降低和硬脂酰辅酶A去饱和酶1（Scd1）表达升高有关。这些结果表明，HFD + EY通过改变脂质代谢显著改善了由HFD引起的血脂异常，而ND + EY对与血脂异常风险相关的生物标志物没有不利影响，但与HFD + EY相比，其对脂质代谢的调节作用不太明显。