使用舒更葡糖钠治疗罗库溴铵过敏反应：以支气管痉挛为唯一症状的病例报告
Treatment of Anaphylaxis to Rocuronium with Sugammadex: A Case Report with Bronchospasm as the Only Symptom.
作者信息
De La Cruz Itziar, Errando Carlos, Calaforra Susana
机构信息
Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University General Hospital, Valencia, Spain.
Department of Allergy and Clinical Immunology, La Fe University and Polytechnic Hospital, Valencia, Spain.
出版信息
Turk J Anaesthesiol Reanim. 2019 Feb;47(1):69-72. doi: 10.5152/TJAR.2019.21298. Epub 2019 Feb 1.
Anaphylaxis during anaesthesia is a rare event occurring in up to 1:20,000 anaesthetics and in 33%-63% neuromuscular blocking agents are involved. Several case reports suggested the effectiveness of sugammadex in the treatment of rocuronium-induced anaphylactic shock refractory to conventional treatment. We report a case of anaphylactic reaction to rocuronium that caused isolated respiratory symptoms and showed no improvement in oxygen saturation after intravenous corticosteroids and intratracheal beta-2 agonists and that was successfully treated with sugammadex. The underlying pathophysiological mechanisms that explain the potential beneficial effect of sugammadex in this context are not completely known. We briefly review the literature regarding this topic.
麻醉期间的过敏反应是一种罕见事件，发生率高达1/20000麻醉病例，其中33%-63%与神经肌肉阻滞剂有关。几例病例报告提示，舒更葡糖在治疗常规治疗无效的罗库溴铵诱导的过敏性休克方面有效。我们报告1例对罗库溴铵的过敏反应，该反应仅引起呼吸系统症状，静脉注射皮质类固醇和气管内给予β2激动剂后血氧饱和度无改善，而舒更葡糖成功治愈了该病例。在这种情况下，解释舒更葡糖潜在有益作用的潜在病理生理机制尚不完全清楚。我们简要回顾了关于该主题的文献。
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