Liao Gang, Zhou Tao, Yao Qi-Jun, Shi Bing-Feng
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China.
Chem Commun (Camb). 2019 Jul 18;55(59):8514-8523. doi: 10.1039/c9cc03967h.
Axially chiral biaryl motifs are widely present in natural products and pharmaceuticals. Moreover, they have been broadly used as privileged ligands in asymmetric catalysis. Over the past few decades, the efficient synthesis of axially chiral biaryls has been a research topic of great interest. This feature article will provide an overview of recent advances in the synthesis of these chiral skeletons via transition metal-catalysed asymmetric C-H functionalization.
轴手性联芳基结构广泛存在于天然产物和药物中。此外，它们还被广泛用作不对称催化中的优势配体。在过去几十年里，轴手性联芳基的高效合成一直是一个备受关注的研究课题。这篇专题文章将概述通过过渡金属催化的不对称C-H官能化合成这些手性骨架的最新进展。
