Armstrong V W, Niedmann D, Eisenhauer T, Janning G, Wagner H, Schuff-Werner P, Seidel D
Abteilung für Klinische Chemie, Universitätsklinikum, Göttingen.
Klin Wochenschr. 1988 Feb 1;66(3):123-8. doi: 10.1007/BF01774226.
Serum alpha-tocopherol and retinol concentrations were followed in four heterozygous adults and one homozygous child with familial hypercholesterolemia being treated by regular low-density lipoprotein (LDL) apheresis. Approximately 50% of plasma alpha-tocopherol was eliminated during a single apheresis procedure in the heterozygous adults, while a complete elimination of this vitamin along with LDLs was observed in the homozygous child. Absolute losses of alpha-tocopherol amounted to 13.4-22.5 mg/apheresis and are equivalent to the recommended dietary intake for 1.5 to 2 days. Despite these losses, no changes were observed either in serum alpha-tocopherol levels or in the ratio of alpha-tocopherol/total serum lipids after 12 months regular apheresis treatment. Serum retinol concentrations only showed a small decrease on apheresis, there being apparently no specific elimination of this vitamin. The absolute losses ranged from 42-422 micrograms/apheresis and were, therefore, much lower than the recommended dietary intake of the equivalent of 1500 micrograms retinol/day. It is concluded that no extra supplementation of these vitamins is required during LDL-apheresis therapy, although it may be advisable to monitor vitamin E status in patients on long-term, intensive therapy.
对4名杂合子成年患者和1名纯合子儿童进行观察，这些家族性高胆固醇血症患者正在接受定期的低密度脂蛋白（LDL）单采治疗，监测他们血清中的α-生育酚和视黄醇浓度。杂合子成年患者在单次单采过程中约50%的血浆α-生育酚被清除，而在纯合子儿童中观察到这种维生素与LDL一起被完全清除。α-生育酚的绝对损失量为13.4 - 22.5毫克/次单采，相当于1.5至2天的推荐膳食摄入量。尽管有这些损失，但在12个月的定期单采治疗后，血清α-生育酚水平或α-生育酚/总血清脂质的比例均未观察到变化。血清视黄醇浓度在单采时仅略有下降，显然没有这种维生素的特异性清除。绝对损失范围为42 - 422微克/次单采，因此远低于相当于1500微克视黄醇/天的推荐膳食摄入量。结论是，在LDL单采治疗期间不需要额外补充这些维生素，尽管对于长期接受强化治疗的患者，监测维生素E状态可能是可取的。
