Blomgren H
Int Arch Allergy Appl Immunol. 1979;59(2):192-8. doi: 10.1159/000232258.
Culture supernatants of PHA-activated human lymphocytes (active SUPs) contain factors which are strongly mitogenic for fractionated peripheral T cells. This stimulation is suppressed by certain non-T lymphocytes. It is shown that these suppressor cells can inhibit an ongoing response of T cells to active SUP and that this inhibition is reversible. Using various rosette sedimentation techniques for fractionating subpopulations of lymphocytes it is concluded that the suppressor cells lack membrane-associated receptors for C3 but possess receptors for the Fc part of IgG. This subset of lymphocytes may be an important regulator of lymphocyte proliferation during immune responses.
PHA激活的人淋巴细胞的培养上清液（活性上清液）含有对分离的外周T细胞具有强烈促有丝分裂作用的因子。这种刺激受到某些非T淋巴细胞的抑制。结果表明，这些抑制细胞可以抑制T细胞对活性上清液的持续反应，并且这种抑制是可逆的。使用各种玫瑰花结沉降技术分离淋巴细胞亚群，得出的结论是，抑制细胞缺乏C3的膜相关受体，但具有IgG的Fc部分的受体。这种淋巴细胞亚群可能是免疫反应期间淋巴细胞增殖的重要调节因子。
