外泌体 circRNAs：生成、作用及在人类疾病中的应用。
Exosomal circRNAs: biogenesis, effect and application in human diseases.
机构信息
Key Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
出版信息
Mol Cancer. 2019 Jul 5;18(1):116. doi: 10.1186/s12943-019-1041-z.
Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circular RNAs have been identified for their enrichment and stability in exosomes. In this review, we outline the origin, biogenesis and function of exosomal circRNAs as well as their roles in various diseases. Although their precise roles and mechanisms of gene regulation remain largely elusive, exosomal circRNAs have potential applications as disease biomarkers and novel therapeutic targets.
外泌体通过调节细胞间的多种生物学过程，在局部和全身范围内成为细胞间通讯的关键介质。环状 RNA (circRNA) 是内源性非编码 RNA 的新成员，具有广泛的分布和多种细胞功能。最近，环状 RNA 因其在外泌体中的富集和稳定性而被鉴定出来。在这篇综述中，我们概述了外泌体环状 RNA 的起源、生物发生和功能，以及它们在各种疾病中的作用。尽管它们的确切作用和基因调控机制在很大程度上仍不清楚，但外泌体环状 RNA 具有作为疾病生物标志物和新型治疗靶点的应用潜力。
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