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NGRID:一种用于检测和评估黄斑病变引起的视觉扭曲的新型平台。

NGRID: A novel platform for detection and progress assessment of visual distortion caused by macular disorders.

机构信息

Biologically Inspired Sensors and Actuators (BioSA) Laboratory, Canada; Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, Canada.

Biologically Inspired Sensors and Actuators (BioSA) Laboratory, Canada; Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, Canada.

出版信息

Comput Biol Med. 2019 Aug;111:103340. doi: 10.1016/j.compbiomed.2019.103340. Epub 2019 Jun 26.

Abstract

This paper presents a new graphical macular interface system (GMIS) for accurate, rapid, and quantitative measurement of visual distortion (VD) in the central vision of patients suffering from macular disorders. In this system, a series of predefined graphical patterns or multiple grids (NGRID) are randomly selected from a library of patterns and visualized on the screen, then the VDs identified by the patient are recorded as binary codes using various control methods including speech recognition. Scalable Vector Graphics (SVG) is used to generate the patterns and save them into a central library. Based on the projected patterns and the patients' responses, a VD graph or so-called heatmap is generated for eye-care purposes. We demonstrate and discuss the functionality of the proposed system for the detection and progress assessment of a macular condition in patients suffering from Central Serous Chorioretinopathy (CSR). Also, we characterize the proposed technique to evaluate the systematic error and response time on healthy human subjects with normal vision. Based on these results, the voice recognition input method exhibits a lower error but a higher response time compared to other input devices. We run the proposed NGRID VD technique to evaluate the effect of CSR on the visual field of a CSR patient. The generated heatmaps are in agreement with standard Optical Coherence Tomography (OCT) images obtained at different times from both the left and right eyes. These results reveal the applicability of the proposed technique for the detection and assessment of macular disorders. Based on these results, the proposed NGRID platform shows great promise for use as an alternative solution for in-home monitoring of various macular disorders and as a means of forwarding responses to secured cloud facilities for future data analysis.

摘要

本文提出了一种新的图形黄斑界面系统 (GMIS),用于准确、快速和定量测量黄斑病变患者中心视力的视觉扭曲 (VD)。在该系统中,一系列预定义的图形模式或多个网格 (NGRID) 从模式库中随机选择并显示在屏幕上,然后使用各种控制方法(包括语音识别)记录患者识别的 VD 作为二进制代码。可伸缩矢量图形 (SVG) 用于生成模式并将其保存到中央库中。基于投影的模式和患者的响应,生成 VD 图或所谓的热图,用于眼保健目的。我们演示和讨论了所提出的系统在检测和评估患有中心性浆液性脉络膜视网膜病变 (CSR) 的患者的黄斑状况方面的功能。此外,我们还对该技术进行了特征描述,以评估正常视力的健康人类受试者的系统误差和响应时间。基于这些结果,与其他输入设备相比,语音识别输入方法的错误率较低,但响应时间较长。我们运行所提出的 NGRID VD 技术来评估 CSR 对 CSR 患者视野的影响。生成的热图与从左眼和右眼在不同时间获得的标准光学相干断层扫描 (OCT) 图像一致。这些结果表明,所提出的技术可用于检测和评估黄斑病变。基于这些结果,所提出的 NGRID 平台有望成为各种黄斑疾病家庭监测的替代解决方案,以及将响应转发到安全的云设施进行未来数据分析的手段。

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