Department of Obstetrics and Gynaecology, Milton Keynes University Hospital, Milton Keynes, UK.
Nuffield Department of Women's and Reproductive Health, University of Oxford, UK; Fetal Medicine Unit, The Women's Centre, John Radcliffe Hospital, Oxford, UK.
Placenta. 2019 Sep 1;84:32-36. doi: 10.1016/j.placenta.2019.06.379. Epub 2019 Jun 26.
Fetal growth restriction (FGR) is a major cause of perinatal morbidity and mortality. Identifying which pregnancies are at risk of FGR facilitates enhanced surveillance and early delivery before fetal demise can ensue. However, existing risk stratification strategies yield an unacceptably low detection rate. A robust and reliable first trimester screening test for FGR would not only enable high-risk women to be appropriately monitored but would facilitate future trials for possible interventions to enhance fetal growth. Both the volume and vascularity of the first trimester placenta has been demonstrated to be linked to adverse pregnancy outcomes including FGR and pre-eclampsia. The investigation of novel ultrasound markers for FGR are discussed along with the development of methods for fully automatic placental volume estimation which has the potential for use as part of a multi-variable population-based screening test.
胎儿生长受限（FGR）是围产儿发病率和死亡率的主要原因。确定哪些妊娠有发生 FGR 的风险，可以便于加强监测，并在胎儿死亡发生之前尽早分娩。然而，现有的风险分层策略的检测率低得令人无法接受。一个强大且可靠的 FGR 早期筛查测试不仅可以使高危妇女得到适当的监测，还可以为可能的干预措施以促进胎儿生长的未来试验提供便利。第一孕期胎盘的体积和血流已被证明与不良的妊娠结局有关，包括 FGR 和子痫前期。本文讨论了 FGR 的新型超声标志物的研究，以及完全自动胎盘体积估计算法的发展，该算法有可能作为多变量基于人群的筛查测试的一部分。
