Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan
Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.
In Vivo. 2019 Jul-Aug;33(4):1341-1346. doi: 10.21873/invivo.11609.
BACKGROUND/AIM: Several studies have investigated prognostic factors in patients with T2 gastric cancer, but no consensus has been reached to date. The aim was to investigate the clinicopathological significance of the status of tumor invasion into the muscularis propria (MP) in T2 gastric cancer patients.
A total of 113 patients with T2 cancer were enrolled. The status of caner invasion was analyzed according to width (extent of horizontal invasion) and depth (extent of vertical invasion).
The prognosis of the group with wide width of invasion (≥1.5 cm) was significantly poorer than that of the group with narrow width of invasion (<1.5 cm) (p=0.001). Multivariate analysis identified the width, and not the depth, as an independent prognostic factor. The analysis according to AJCC N stage showed that the width, and not the nodal status, was an independent prognostic factor in the N2-N3 patients (p=0.005).
Measurement of the width of tumor invasion into the MP was useful to understand the malignant potential of T2 gastric cancer.
背景/目的：多项研究已经调查了 T2 期胃癌患者的预后因素，但迄今为止尚未达成共识。本研究旨在探讨 T2 期胃癌患者肿瘤侵犯肌层（MP）状态的临床病理意义。
共纳入 113 例 T2 期癌症患者。根据肿瘤的宽度（水平侵犯的程度）和深度（垂直侵犯的程度）分析癌症侵犯的状态。
侵犯宽度≥1.5cm 的患者的预后明显差于侵犯宽度<1.5cm 的患者（p=0.001）。多变量分析确定宽度而非深度是独立的预后因素。根据 AJCC N 分期进行的分析表明，宽度而非淋巴结状态是 N2-N3 患者的独立预后因素（p=0.005）。
测量肿瘤侵犯 MP 的宽度有助于了解 T2 期胃癌的恶性潜能。
