AJCC/UICC第8版分期系统在胃癌中的预后作用：一项回顾性分析
The prognosis role of AJCC/UICC 8 edition staging system in gastric cancer, a retrospective analysis.
作者信息
Liu Jiu-Yang, Peng Chun-Wei, Yang Xiao-Jun, Huang Chao-Qun, Li Yan
机构信息
Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study CenterNo. 169 Donghu Road, Wuchang District, Wuhan 430071, P. R. China.
Department of Peritoneal Cancer Surgery, Cancer Center of Beijing Shijitan Hospital Affiliated to The Capital Medical UniversityNo. 10 Tieyi Road, Yangfangdian, Beijing 100038, P. R. China.
出版信息
Am J Transl Res. 2018 Jan 15;10(1):292-303. eCollection 2018.
Abstract
OBJECTIVE
The present study was designed to investigate whether AJCC/UICC 8 edition staging system precisely differentiated patients with different prognosis of gastric cancer (GC).
METHODS
There were 540 GC cases included in this study. Stratification was done according to the 7 and 8 AJCC/UICC tumor-node-metastasis (TNM) staging systems. Detailed comparison was conducted between two editions in terms of the sub-classification of pN3 stage, redefinitions of stage III, homogeneity, discrimination power, predictive accuracy, and complexity.
RESULTS
Compared to the 7 edition, the 8 TNM staging system performed better by incorporating pN3a and pN3b into the final stage of GC (<0.001), had better stage grouping homogeneity (<0.001), prognostic value (area under the curve, AUC-value was 0.809), and comparable discrimination power.
CONCLUSIONS
AJCC 8 TNM staging system showed improved efficiency in GC prognosis.
摘要
目的
本研究旨在调查美国癌症联合委员会/国际抗癌联盟（AJCC/UICC）第8版分期系统是否能准确区分不同预后的胃癌（GC）患者。
方法
本研究纳入了540例GC病例。根据AJCC/UICC第7版和第8版肿瘤-淋巴结-转移（TNM）分期系统进行分层。对两版在pN3期的亚分类、III期的重新定义、同质性、区分能力、预测准确性和复杂性方面进行了详细比较。
结果
与第7版相比，第8版TNM分期系统通过将pN3a和pN3b纳入GC的最终分期表现更好（<0.001），具有更好的分期分组同质性（<0.001）、预后价值（曲线下面积，AUC值为0.809）和相当的区分能力。
结论
AJCC第8版TNM分期系统在GC预后方面显示出更高的效率。
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