Zi Hao, Wang Xue-Jun, Zhao Ming-Juan, Huang Qiao, Wang Xing-Huan, Zeng Xian-Tao
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Aging (Albany NY). 2019 Jul 3;11(13):4438-4445. doi: 10.18632/aging.102061.
Evidence suggests there maybe an association among abnormal fasting blood glucose, hypertension and benign prostatic hyperplasia. In this study, we investigated whether abnormal fasting blood glucose correlates with hypertension in aging benign prostatic hyperplasia patients. Ultimately, 612 benign prostatic hyperplasia patients, including 230 hypertensive patients and 382 normotensive patients, were included. Univariate and multivariate logistic regression analyses were used to evaluate the associations. The results indicated that neither impaired fasting glucose/high risk of type 2 diabetes mellitus nor high risk of type 2 diabetes mellitus were associated with an increased risk of hypertension. When patients were stratified based on the severity of their hypertension, similar results were obtained (all > 0.05). After adjusting for confounding factors, the nonsignificant tendencies for high risk of type 2 diabetes mellitus and impaired fasting glucose/high risk of type 2 diabetes mellitus to associate with hypertension persisted (all > 0.05). Unlike earlier studies, the present study suggests that the level of fasting blood glucose may not be significantly related to hypertension in aging patients with benign prostatic hyperplasia.
有证据表明，空腹血糖异常、高血压和良性前列腺增生之间可能存在关联。在本研究中，我们调查了老年良性前列腺增生患者空腹血糖异常与高血压之间是否存在相关性。最终，纳入了612例良性前列腺增生患者，其中包括230例高血压患者和382例血压正常的患者。采用单因素和多因素逻辑回归分析来评估相关性。结果表明，空腹血糖受损/2型糖尿病高风险和2型糖尿病高风险均与高血压风险增加无关。当根据患者高血压的严重程度进行分层时，得到了相似的结果（均>0.05）。在调整混杂因素后，2型糖尿病高风险和空腹血糖受损/2型糖尿病高风险与高血压相关的无显著趋势仍然存在（均>0.05）。与早期研究不同，本研究表明，老年良性前列腺增生患者的空腹血糖水平可能与高血压无显著相关性。
