Orlandi E, Alessandrino E P, Caldera D, Bernasconi C
Divisione di Ematologia, Policlinico S. Matteo IRCCS, Pavia, Italia.
Acta Haematol. 1988;79(3):174-7. doi: 10.1159/000205752.
481 cases of adult leukemia (115 acute lymphoblastic leukemia, ALL, and 366 acute nonlymphoid leukemia, ANLL) diagnosed at the Hematology Division of Pavia between 1976 and 1985 were reviewed to evaluate how many patients had an aplastic presentation. In 8 cases (1.6%) typical marrow hypoplasia preceded overt leukemia. At the leukemic transformation, the morphological and immunological findings were diagnostic for non-T non-B ALL in 2 cases, for ANLL in 5 cases (2 M1, 2 M2, 1 M5) and for Ph'-negative chronic granulocytic leukemia in 1 case. Median survival from the onset of leukemia was 5 months. In a certain proportion of cases aplastic anemia may be considered as a preleukemic state with a low propensity to develop into acute leukemia.
回顾了1976年至1985年间在帕维亚血液科诊断的481例成人白血病患者（115例急性淋巴细胞白血病，ALL，以及366例急性非淋巴细胞白血病，ANLL），以评估有多少患者呈现再生障碍性表现。8例（1.6%）患者在明显白血病之前出现典型的骨髓增生低下。在白血病转化时，形态学和免疫学检查结果诊断为非T非B ALL的有2例，诊断为ANLL的有5例（2例M1、2例M2、1例M5），诊断为Ph'-阴性慢性粒细胞白血病的有1例。白血病发病后的中位生存期为5个月。在一定比例的病例中，再生障碍性贫血可被视为白血病前期状态，发展为急性白血病的倾向较低。
