Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Clin Transl Oncol. 2020 Mar;22(3):283-293. doi: 10.1007/s12094-019-02147-2. Epub 2019 Jul 6.
Leukemic cells' (LCs) survival, proliferation, activation, differentiation, and invasiveness/migration can be mediated through the function of cation and anion channels that are involved in volume regulation, polarization, cytoskeleton, and extracellular matrix reorganization. This study will review the expression of ion channels in LCs and their possible function in leukemia progression. We searched relevant literature by a PubMed (2002-2019) of English-language literature using the terms "ion channels", "leukemia", "proliferation", "differentiation", "apoptosis", and "migration". Altered expression and dysfunction of ion channels can have a strong impact on hematopoietic cell and LCs physiology and signaling, which contributes to the vital processes such as proliferation, differentiation, and apoptosis. Indeed, it can be stated that changing expression of ion channels can affect the onset and progression as well as clinical features and therapeutic responses of leukemia via inducing the maintenance of LCs. Since ion channels are membrane proteins, they can be easily accessible in LCs for understanding their influence on leukemia progression. On the other hand, ion channels can be new potential targets for chemotherapeutic agents, which may open a novel clinical and pharmaceutical field in leukemia therapy.
白血病细胞 (LCs) 的存活、增殖、激活、分化和侵袭/迁移可通过参与体积调节、极化、细胞骨架和细胞外基质重排的阳离子和阴离子通道的功能来介导。本研究将综述 LC 中离子通道的表达及其在白血病进展中的可能作用。我们通过 PubMed（2002-2019 年）以英文文献为基础，使用了“离子通道”、“白血病”、“增殖”、“分化”、“凋亡”和“迁移”等术语搜索了相关文献。离子通道表达的改变和功能障碍会对造血细胞和 LCs 的生理学和信号转导产生强烈影响，这有助于增殖、分化和凋亡等重要过程。事实上，可以说改变离子通道的表达可以通过诱导 LCs 的维持来影响白血病的发生和进展以及临床特征和治疗反应。由于离子通道是膜蛋白，因此它们在 LCs 中很容易被识别，从而可以了解它们对白血病进展的影响。另一方面，离子通道可能成为化疗药物的新潜在靶点，这可能为白血病治疗开辟新的临床和药物领域。
