Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus Medical Center, Rotterdam, the Netherlands.
Int J Cardiol. 2020 Jan 15;299:276-281. doi: 10.1016/j.ijcard.2019.06.010. Epub 2019 Jun 15.
Although the descending aortic diameter is larger in smokers, data about thoracic aortic growth is missing. Our aim is to present the distribution of thoracic aortic growth in smokers and to compare it with literature of the general population.
Current and ex-smokers aged 50-70 years from the longitudinal Danish Lung Cancer Screening Trial, were included. Mean and 95th percentile of annual aortic growth of the ascending aortic (AA) and descending aortic (DA) diameters were calculated with the first and last non-contrast computed tomography scans during follow-up. Determinants of change in aortic diameter over time were investigated with linear mixed models.
A total of 1987 participants (56% male, mean age 57.4 ± 4.8 years) were included. During a median follow-up of 48 months, mean AA and DA growth rates were comparable between males (AA 0.12 ± 0.31 mm/year and DA 0.10 ± 0.30 mm/year) and females (AA 0.11 ± 0.29 mm/year and DA 0.13 ± 0.27 mm/year). The 95th percentile ranged from 0.42 to 0.47 mm/year, depending on sex and location. Aortic growth was comparable between current and ex-smokers and aortic growth was not associated with pack-years. Our findings are consistent with aortic growth rates of 0.08 to 0.17 mm/years in the general population. Larger aortic growth was associated with lower age, increased height, absence of medication for hypertension or hypercholesterolemia and lower Agatston scores.
This longitudinal study of smokers in the age range of 50-70 years shows that ascending and descending aortic growth is approximately 0.1 mm/year and is consistent with growth in the general population.
尽管吸烟者的降主动脉直径较大，但有关胸主动脉生长的数据尚不清楚。我们的目的是展示吸烟者胸主动脉生长的分布，并将其与一般人群的文献进行比较。
本研究纳入了来自纵向丹麦肺癌筛查试验的年龄在 50-70 岁之间的当前吸烟者和已戒烟者。在随访期间，通过首次和最后一次非对比计算机断层扫描（CT）计算升主动脉（AA）和降主动脉（DA）直径的年平均和第 95 百分位数增长率。使用线性混合模型研究随时间变化主动脉直径变化的决定因素。
共纳入 1987 名参与者（56%为男性，平均年龄 57.4±4.8 岁）。在中位数为 48 个月的随访期间，男性（AA 0.12±0.31mm/年和 DA 0.10±0.30mm/年）和女性（AA 0.11±0.29mm/年和 DA 0.13±0.27mm/年）的 AA 和 DA 生长速度相当。95 百分位数范围因性别和位置而异，范围为 0.42-0.47mm/年。当前吸烟者和已戒烟者的主动脉生长情况相当，且与吸烟年限无关。我们的研究结果与一般人群中 0.08-0.17mm/年的主动脉生长速度一致。更大的主动脉生长与年龄较小、身高较高、无高血压或高胆固醇血症药物治疗以及较低的 Agatston 评分有关。
本研究对年龄在 50-70 岁之间的吸烟者进行了纵向研究，结果表明升主动脉和降主动脉的生长速度约为 0.1mm/年，与一般人群的生长速度一致。
