Nottingham University Hospitals NHS Trust, Nottingham, UK.
University of Nottingham, Faculty of Medicine and Health Sciences, Nottingham, UK.
Eur J Cardiothorac Surg. 2023 Oct 4;64(4). doi: 10.1093/ejcts/ezad302.
Screening for lung cancer with low radiation dose computed tomography has a strong evidence base, is being introduced in several European countries and is recommended as a new targeted cancer screening programme. The imperative now is to ensure that implementation follows an evidence-based process that will ensure clinical and cost effectiveness. This European Respiratory Society (ERS) task force was formed to provide an expert consensus for the management of incidental findings which can be adapted and followed during implementation.
A multi-European society collaborative group was convened. 23 topics were identified, primarily from an ERS statement on lung cancer screening, and a systematic review of the literature was conducted according to ERS standards. Initial review of abstracts was completed and full text was provided to members of the group for each topic. Sections were edited and the final document approved by all members and the ERS Science Council.
Nine topics considered most important and frequent were reviewed as standalone topics (interstitial lung abnormalities, emphysema, bronchiectasis, consolidation, coronary calcification, aortic valve disease, mediastinal mass, mediastinal lymph nodes and thyroid abnormalities). Other topics considered of lower importance or infrequent were grouped into generic categories, suitable for general statements.
This European collaborative group has produced an incidental findings statement that can be followed during lung cancer screening. It will ensure that an evidence-based approach is used for reporting and managing incidental findings, which will mean that harms are minimised and any programme is as cost-effective as possible.
低剂量计算机断层扫描肺癌筛查具有坚实的证据基础，已在几个欧洲国家开展，并被推荐作为一种新的靶向癌症筛查计划。现在当务之急是确保实施遵循基于证据的流程，以确保临床和成本效益。成立这个欧洲呼吸学会（ERS）工作组是为了提供管理偶然发现的专家共识，以便在实施过程中进行调整和遵循。
召集了一个多欧洲学会合作小组。确定了 23 个主题，主要来自 ERS 关于肺癌筛查的声明，根据 ERS 标准对文献进行了系统回顾。完成了对摘要的初步审查，并为小组的每个主题提供了全文。编辑了各部分，最终文件由所有成员和 ERS 科学委员会批准。
审查了 9 个被认为最重要和最常见的主题作为独立主题（间质性肺异常、肺气肿、支气管扩张、实变、冠状动脉钙化、主动脉瓣疾病、纵隔肿块、纵隔淋巴结和甲状腺异常）。其他被认为重要性较低或不常见的主题被归入通用类别，适合一般性陈述。
这个欧洲合作小组已经制定了偶然发现声明，可以在肺癌筛查期间遵循。这将确保使用基于证据的方法报告和管理偶然发现，这意味着将最大限度地减少危害，使任何计划都尽可能具有成本效益。
