Jaremko Inna, Mačiulienė Asta, Gelmanas Arūnas, Baranauskas Tautvydas, Tamošiūnas Ramūnas, Smailys Alfredas, Macas Andrius
Department of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Acta Med Litu. 2019;26(1):1-7. doi: 10.6001/actamedica.v26i1.3948.
The study was performed at the Department of Orthopaedics and Traumatology of the Kauno Klinikos Hospital of Lithuanian University of Health Sciences.
Intravascular fluids are empirically administered to prevent hypotension induced by spinal anaesthesia. Ultrasound measurements of the inferior vena cava (IVC) and the IVC collapsibility index (IVC-CI) is a non-invasive method to evaluate the intravascular volume status. The aim of the study was to identify the prognostic value of the IVC collapsibility index in spontaneously breathing patients to predict severe intraoperative hypotension.
Sixty patients undergoing elective knee arthroplasty under spinal anaesthesia were included in the prospective study. The diameters of IVC, IVC, and IVC-CI were measured before and 15 min after spinal anaesthesia when administration of 500 ml of normal saline using infusion pump was finished. The haemodynamic parameters (heart rate, systolic, diastolic, and mean blood pressures, breathing rate) were collected.
Severe arterial hypotension was noticed in 18.3% of the patients. No statistically significant differences were detected between changes in IVC, IVC, and IVC-CI comparing hypotensive and non-hypotensive patients at the baseline and after the interventions ( > 0.005). According to receiver operating characteristic (ROC) analysis, IVC-CI is not effective in the prediction of severe hypotension during spinal anaesthesia in spontaneously breathing patients: the area under the ROC curve for IVC-CI was <0.7, > 0.05.
IVC-CI is not an effective predictor of severe hypotension after induction of spinal anaesthesia followed by normal saline administration in spontaneously breathing patients undergoing elective knee arthroplasty. More trials, including different patient subgroups, will be needed.
该研究在立陶宛卫生科学大学考纳斯临床医院骨科与创伤科进行。
临床上通常给予血管内液体以预防脊髓麻醉引起的低血压。超声测量下腔静脉(IVC)及其塌陷指数(IVC-CI)是评估血管内容量状态的一种非侵入性方法。本研究的目的是确定IVC塌陷指数在自主呼吸患者中预测严重术中低血压的预后价值。
前瞻性研究纳入了60例接受脊髓麻醉下行择期膝关节置换术的患者。在使用输液泵输注500ml生理盐水结束后,于脊髓麻醉前和麻醉后15分钟测量IVC的直径、IVC及IVC-CI。收集血流动力学参数(心率、收缩压、舒张压、平均血压、呼吸频率)。
18.3%的患者出现严重动脉低血压。在基线和干预后,比较低血压和非低血压患者的IVC、IVC及IVC-CI变化,未发现统计学显著差异(>0.005)。根据受试者操作特征(ROC)分析,IVC-CI在预测自主呼吸患者脊髓麻醉期间的严重低血压方面无效:IVC-CI的ROC曲线下面积<0.7,>0.05。
对于接受择期膝关节置换术的自主呼吸患者,在脊髓麻醉诱导并给予生理盐水后,IVC-CI并非严重低血压的有效预测指标。需要进行更多试验,包括不同的患者亚组。