Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht 3508GA, The Netherlands.
Theranostics. 2019 May 31;9(14):4030-4046. doi: 10.7150/thno.33112. eCollection 2019.
Heart diseases are one of the leading causes of death for humans in the world. Increasing evidence has shown that myocardial injury induced innate and adaptive immune responses upon early cellular damage but also during chronic phases post-injury. The immune cells can not only aggravate the injury but also play an essential role in the induction of wound healing responses, which means they play a complex role throughout the acute inflammatory response and reparative response after cardiac injury. This review will summarize the current experimental and clinical evidence of lymphocytes, one of the major types of immune cells, participate in heart diseases and try to explain the possible role of these immune cells following cardiac injury.
心脏病是世界上导致人类死亡的主要原因之一。越来越多的证据表明，心肌损伤不仅在早期细胞损伤时，而且在损伤后慢性期也会引起先天和适应性免疫反应。免疫细胞不仅会加重损伤，而且在诱导伤口愈合反应中也起着至关重要的作用，这意味着它们在心脏损伤后的急性炎症反应和修复反应中起着复杂的作用。本综述将总结淋巴细胞（主要免疫细胞之一）参与心脏病的现有实验和临床证据，并试图解释这些免疫细胞在心脏损伤后的可能作用。
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