伤口愈合：免疫学方面

Wound healing: immunological aspects.

作者信息

Tsirogianni Afrodite K, Moutsopoulos Niki Maria, Moutsopoulos Haralampos M

机构信息

Department of Pathophysiology, Medical School, University of Athens, 75, M. Asias Street, Athens 115 27, Greece.

出版信息

Injury. 2006 Apr;37 Suppl 1:S5-12. doi: 10.1016/j.injury.2006.02.035. Epub 2006 Apr 17.

DOI:10.1016/j.injury.2006.02.035

PMID:16616753

Abstract

Wound healing is a complex biological process, comprised of a series of a sequential events aiming to repair injured tissue. The role of the immune system in this process is not only to recognise and combat the newly presented antigens at the site of injury, but also to participate in the debridement of the damaged area and to contribute to the process of healing. In this review, we discuss the molecules and cells of the immune system that participate in tissue repair. We describe the mechanisms of immune recognition during initial insult and the innate and adaptive immune responses to injury. Finally, we address the role of the immune system in regeneration and repair.

摘要

伤口愈合是一个复杂的生物学过程，由一系列旨在修复受损组织的连续事件组成。免疫系统在这一过程中的作用不仅是识别和对抗损伤部位新出现的抗原，还参与受损区域的清创，并促进愈合过程。在本综述中，我们讨论参与组织修复的免疫系统分子和细胞。我们描述了初始损伤时的免疫识别机制以及对损伤的固有免疫和适应性免疫反应。最后，我们阐述免疫系统在再生和修复中的作用。