一种用于慢性足部溃疡成像的便携式三维光声断层扫描系统。
A portable three-dimensional photoacoustic tomography system for imaging of chronic foot ulcers.
作者信息
Wang Yuehang, Zhan Ye, Harris Linda M, Khan Sikandar, Xia Jun
机构信息
Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York, USA.
Department of Surgery, University at Buffalo, The State University of New York, Buffalo, New York, USA.
出版信息
Quant Imaging Med Surg. 2019 May;9(5):799-806. doi: 10.21037/qims.2019.05.02.
BACKGROUND
Chronic leg ulcers affect approximately 6.5 million Americans and the disorder is associated with a range of serious complications. Since many chronic ulcers have underlying vascular insufficiency, accurate assessment of tissue perfusion is critical to treatment planning and post-surgical monitoring. However, existing clinical tests fail to meet this need in practice due to their low sensitivity or accuracy.
METHODS
In this paper, we introduce a portable photoacoustic tomography (PAT) system for wound assessment. Since hemoglobin serves as the major endogenous contrast at near-infrared wavelengths, PAT provides label-free, three-dimensional (3D) imaging of hemoglobin distribution, which is closely related to blood perfusion. The proposed system consists of a 128-element linear transducer array, a data acquisition (DAQ) system, and a pulsed Nd:YAG laser source, all mounted on a portable cart for easy clinical testing.
RESULTS
We validated our system through both phantom and human imaging studies. The phantom imaging results indicate that the system's spatial resolution ranges from 0.5 mm along the axial direction to 1.3 mm along the elevational direction. The healthy volunteer result shows clear foot vasculature, indicating good perfusion. The preliminary patient imaging results agree very well with the clinical test, demonstrating that PAT has a high potential for assessing the circulation around the wound.
CONCLUSIONS
We believe that our technique will be a valuable tool for assessing tissue perfusion and guiding wound treatment in vascular clinics.
背景
慢性腿部溃疡影响着约650万美国人，且该病症与一系列严重并发症相关。由于许多慢性溃疡存在潜在的血管功能不全，准确评估组织灌注对于治疗方案规划和术后监测至关重要。然而，现有的临床检测方法在实际应用中因灵敏度或准确性低而无法满足这一需求。
方法
在本文中，我们介绍一种用于伤口评估的便携式光声断层扫描（PAT）系统。由于血红蛋白在近红外波长下作为主要的内源性对比剂，PAT可提供与血液灌注密切相关的血红蛋白分布的无标记三维（3D）成像。所提出的系统由一个128阵元线性换能器阵列、一个数据采集（DAQ）系统和一个脉冲Nd:YAG激光源组成，所有这些组件都安装在一个便携式推车上，便于进行临床检测。
结果
我们通过体模和人体成像研究验证了我们的系统。体模成像结果表明，该系统的空间分辨率在轴向为0.5毫米，在仰角方向为1.3毫米。健康志愿者的成像结果显示足部血管清晰，表明灌注良好。初步患者成像结果与临床检测结果非常吻合，表明PAT在评估伤口周围血液循环方面具有很高的潜力。
结论
我们相信我们的技术将成为血管诊所评估组织灌注和指导伤口治疗的有价值工具。
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