Opt Lett. 2019 Jan 1;44(1):81-84. doi: 10.1364/OL.44.000081.
Bulky, expensive Nd:YAG lasers are used in conventional photoacoustic tomography (PAT) systems, making them difficult to translate into clinics. Moreover, real-time imaging is not feasible when a single-element ultrasound transducer is used with these low-pulse-repetition-rate lasers (10-100 Hz). Low-cost pulsed laser diodes (PLDs) can be used instead for photoacoustic imaging due to their high-pulse-repetition rates and compact size. Together with acoustic-reflector-based multiple single-element ultrasound transducers, a portable desktop PAT system was developed. This second-generation PLD-based PAT achieved 0.5 s cross-sectional imaging time with high spatial resolution of ∼165 μm and an imaging depth of 3 cm. The performance of this system was characterized using phantom and in vivo studies. Dynamic in vivo imaging was also demonstrated by monitoring the fast uptake and clearance of indocyanine green in small animal (rat) brain vasculature.
笨重、昂贵的 Nd:YAG 激光器用于传统的光声断层扫描（PAT）系统，这使得它们难以转化为临床应用。此外，当使用这些低脉冲重复率激光器（10-100 Hz）与单个元件超声换能器时，实时成像不可行。由于高脉冲重复率和紧凑的尺寸，低成本脉冲激光二极管（PLD）可用于光声成像。结合基于声反射器的多个单元件超声换能器，开发了一种便携式台式 PAT 系统。第二代基于 PLD 的 PAT 实现了 0.5 s 的横截面成像时间，具有高空间分辨率约为 165 μm 和 3 cm 的成像深度。通过使用体模和体内研究对该系统的性能进行了表征。还通过监测小动物（大鼠）脑脉管系统中吲哚菁绿的快速摄取和清除来演示了动态体内成像。
