Larrosa Haro Alfredo, Vásquez-Garibay Edgar Manuel, Guzmán-Mercado Elizabeth, Muñoz Esparza Nelly Carolina, García-Arellano Samuel, Muñoz-Valle José Francisco, Romero-Velarde Enrique
Universidad de Guadalajara.
Nutr Hosp. 2019 Aug 26;36(4):799-804. doi: 10.20960/nh.02534.
Objective: we assessed the relationship between serum and human foremilk and hindmilk concentrations of ghrelin and leptin in nursing mothers according to the type of feeding. Methods: this cohort design was carried out on 131 mother-newborn dyads admitted to a physiological puerperium ward. The independent variables were the type of feeding, full breastfeeding (FBF, 56.5%) and partial breastfeeding (PBF, 43.5%). The dependent variables were the concentration of total ghrelin (pg/ml) and leptin (ng/ml) in serum, foremilk and hindmilk at eight and 16 weeks. Fasting blood samples were obtained from the nursing mothers at four months for serum assays. Unpaired Student's t-test, Mann-Whitney U test, Pearson's correlation tests, coefficient of determination and linear regression were used. Results: the concentration of ghrelin and leptin in hindmilk was higher than that of foremilk in both groups at eight and 16 weeks. The concentration of ghrelin and leptin was higher in serum than in foremilk in both groups. These values showed a direct and significant linear correlation with the exception of ghrelin in the FBF group. The serum concentration of leptin in mothers explained 32% of the variance of its concentration in foremilk in the FBF and 13% in the PBF groups. Conclusion: the hindmilk/foremilk gradient suggests an intake regulating mechanism during the fed. The concentration of ghrelin and leptin was higher in the serum than in foremilk and its correlation and determination coefficients could suggest plasma-milk transfer in addition to synthesis regulation by the mammary gland, adipose tissue or other organs.
我们根据喂养方式评估了哺乳期母亲血清、人初乳和后乳中胃饥饿素和瘦素浓度之间的关系。方法：对入住生理性产褥期病房的131对母婴进行了这项队列研究。自变量为喂养方式，即纯母乳喂养（FBF，56.5%）和部分母乳喂养（PBF，43.5%）。因变量为8周和16周时血清、初乳和后乳中总胃饥饿素（pg/ml）和瘦素（ng/ml）的浓度。在四个月时从哺乳期母亲处采集空腹血样进行血清检测。采用非配对学生t检验、曼-惠特尼U检验、皮尔逊相关检验、决定系数和线性回归分析。结果：在8周和16周时，两组后乳中胃饥饿素和瘦素的浓度均高于初乳。两组血清中胃饥饿素和瘦素的浓度均高于初乳。除FBF组的胃饥饿素外，这些值显示出直接且显著的线性相关性。母亲血清中瘦素的浓度在FBF组中解释了其在初乳中浓度变化的32%，在PBF组中解释了13%。结论：后乳/初乳梯度提示喂养期间存在一种摄入调节机制。血清中胃饥饿素和瘦素的浓度高于初乳，其相关性和决定系数除了提示乳腺、脂肪组织或其他器官的合成调节外，还可能提示血浆-乳汁转运。
