Yang Kun, Wang Yan
Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin Eye Institute,Clinical College of Ophthalmology of Tianjin Medical University,Tianjin Eye Hospital,Tianjin 300020,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Jun 30;41(3):425-429. doi: 10.3881/j.issn.1000-503X.11029.
Human optic nerve injury and its associated neurodegenerative diseases are often followed by permanent vision loss.Stem cell therapy has long been considered a promising mode to treat retinal degenerative diseases.Recent studies revealed that there are silent retinal stem cells in the eyes of mammals and even humans.These stem cells can be activated again under certain conditions and differentiate into retinal neurons to repair the damaged retina.Wnt signaling pathway plays a crucial role in conducting growth-stimulating signals and regulates cell proliferation,differentiation and apoptosis.This article review the regulatory effect of Wnt signaling pathway on stem cells-based retinal regeneration and the sources of retinal stem cells.
人类视神经损伤及其相关的神经退行性疾病常常导致永久性视力丧失。长期以来，干细胞疗法一直被认为是治疗视网膜退行性疾病的一种有前景的方式。最近的研究表明，在哺乳动物甚至人类的眼睛中存在静息视网膜干细胞。这些干细胞在某些条件下可以再次被激活，并分化为视网膜神经元以修复受损的视网膜。Wnt信号通路在传导生长刺激信号中起关键作用，并调节细胞增殖、分化和凋亡。本文综述了Wnt信号通路对基于干细胞的视网膜再生的调节作用以及视网膜干细胞的来源。
