Physical Medicine and Rehabilitation, University of Michigan, , , USA.
J Rehabil Med. 2019 Sep 3;51(8):575-581. doi: 10.2340/16501977-2582.
Adults with cerebral palsy have an increased risk of developing osteoarthritis. However, little is known about the epidemiology of osteoarthritis among this vulnerable population. The objectives of this study were to compare the prevalence of osteoarthritis between adults with and without cerebral palsy, and to determine how the prevalence of osteoarthritis changes throughout adulthood for each group.
Data were extracted from the 2016 Optum Clinformatics® Data Mart, a nationwide database of de-identified US insurance claims, containing medical and pharmacy information on beneficiaries.
International Classification of Diseases 10th revision (ICD-10) codes were used to identify adults (18+ years) with (n = 7,348) and without (n = 8.7 million) cerebral palsy.
ICD-10 codes were used to identify osteoarthritis. Prevalence of osteoarthritis was compared between adults with and without cerebral palsy before and after adjusting for age and sex. The prevalence of any type of osteoarthritis was compared between men and women with and without cerebral palsy, stratified by the following age groups: 18-30, 31-40, 41-50, 51-60, 61-70, and > 70 years.
Adults with cerebral palsy had higher prevalence and adjusted odds of any, poly, hip, knee, and other/unspecified osteoarthritis (odds ratio (OR): 1.3-2.1; p < 0.001), but not hand osteoarthritis (OR: 0.86; p = 0.46). Men and women with cerebral palsy had a higher prevalence of any osteoarthritis compared with adults without cerebral palsy across all age groups (all p < 0.05).
Privately-insured adults with cerebral palsy had a higher prevalence of osteoarthritis compared with adults without cerebral palsy across the adult lifespan.
脑瘫成年人患骨关节炎的风险增加。然而，对于这一弱势群体的骨关节炎流行病学知之甚少。本研究的目的是比较脑瘫成年人和非脑瘫成年人骨关节炎的患病率，并确定每组成年人的骨关节炎患病率在整个成年期的变化情况。
从全国范围内的匿名美国保险索赔数据库 Optum Clinformatics® Data Mart 中提取数据，该数据库包含受益人的医疗和药房信息。
使用国际疾病分类第 10 版 (ICD-10) 代码识别患有（n=7348 名）和不患有（n=870 万）脑瘫的成年人。
使用 ICD-10 代码识别骨关节炎。在调整年龄和性别后，比较患有和不患有脑瘫的成年人之间骨关节炎的患病率。比较患有和不患有脑瘫的男性和女性之间各种类型的骨关节炎的患病率，按以下年龄组分层：18-30 岁、31-40 岁、41-50 岁、51-60 岁、61-70 岁和>70 岁。
患有脑瘫的成年人的任何类型、多关节、髋关节、膝关节和其他/未特指的骨关节炎的患病率和调整后的比值比（OR）更高（OR：1.3-2.1；p<0.001），但手部骨关节炎除外（OR：0.86；p=0.46）。在所有年龄组中，患有脑瘫的男性和女性的任何类型骨关节炎的患病率均高于无脑瘫的成年人（所有 p<0.05）。
在整个成年期，私人保险的脑瘫成年人患骨关节炎的患病率高于无脑瘫的成年人。
