Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India.
IUBMB Life. 2019 Nov;71(11):1661-1671. doi: 10.1002/iub.2115. Epub 2019 Jul 8.
Infectious diseases account for a large proportion of global health emergencies and are rising more so owing to the paucity of effective vaccination and chemotherapeutic strategies. The severity is compounded by the development of antibiotic resistance among major pathogenic strains, capable of residing in the hostile host microenvironment by hijacking its signaling mechanisms and molecular circuitry. Among such processes, studies on epidermal growth factor receptor (EGFR) have revealed specific contributions of this classical oncogenic signaling axis during distinct infection conditions. Here, we review the current status of EGFR family members in the context of host-pathogen interactions and speculate the possible dimensions of exploration and manipulation of the EGFR pathway for host-directed therapeutic purposes.
传染病在全球卫生紧急事件中占很大比例，由于缺乏有效的疫苗接种和化疗策略，传染病的发病率更是呈上升趋势。主要病原体菌株对抗生素的耐药性的发展加剧了这种情况，这些病原体菌株能够通过劫持宿主的信号机制和分子电路，在恶劣的宿主微环境中生存。在这些过程中，表皮生长因子受体 (EGFR) 的研究揭示了这条经典致癌信号轴在不同感染条件下的具体贡献。在这里，我们回顾了 EGFR 家族成员在宿主-病原体相互作用中的现状，并推测了探索和操纵 EGFR 途径以达到宿主导向治疗目的的可能方向。
