Andersen E, Pedersen H
Department of Oncology 1, Finsen Institute, Copenhagen, Denmark.
Acta Oncol. 1987;26(6):433-6. doi: 10.3109/02841868709113713.
The toxicities of oral Ftorafur (1 g/m2/day 1-21) and intravenous 5-fluorouracil (5-FU) (500 mg/m2/day 1-5) were compared in a prospective randomized study in patients with colorectal cancer. The treatment courses were repeated every 6th week. Leucopenia was more common after 5-FU. Leucocyte nadir in connection with first treatment cycle was on average seen on day 15 in patients receiving 5-FU and on day 28 in patients receiving Ftorafur. Significantly more patients on 5-FU developed stomatitis. There was no difference in the number of patients with diarrhea or nausea/vomiting. Median survival and response rates were not significantly different after the two treatment schedules.
在一项针对结直肠癌患者的前瞻性随机研究中，比较了口服喃氟啶（1克/平方米，第1 - 21天）和静脉注射5-氟尿嘧啶（5-FU）（500毫克/平方米，第1 - 5天）的毒性。治疗疗程每6周重复一次。5-FU治疗后白细胞减少更为常见。接受5-FU治疗的患者在第一个治疗周期时白细胞最低点平均出现在第15天，而接受喃氟啶治疗的患者则出现在第28天。接受5-FU治疗的患者发生口腔炎的人数明显更多。腹泻或恶心/呕吐患者的数量没有差异。两种治疗方案后的中位生存期和缓解率没有显著差异。
