Li Shifeng, Xu Qiongying
School of Psychology, Northwest Normal University.
Key Laboratory of Behavioral and Mental Health, Lanzhou, China.
Neuroreport. 2019 Aug 14;30(12):852-855. doi: 10.1097/WNR.0000000000001289.
Deficiency in cognitive control has been proposed as a core issue in addictive behavior, and recent advancements in cognitive neuroscience have suggested that frontal midline theta is a mechanism for cognitive control. This study examined frontal midline theta deficits in patients with heroin dependence during a Go/No-go task which explicitly involved cognitive control. Electroencephalography readings were collected from 15 male heroin addicts and 17 demographically matched healthy controls during an equal probability Go/No-go task. The findings revealed that heroin addicts responded significantly slower to the Go stimulus as compared to the healthy control. Heroin addicts also showed less frontal midline theta modulations between the Go and No-go conditions. These findings provided further evidence toward understanding the nature of drug addiction-related cognitive dysfunction.
认知控制缺陷被认为是成瘾行为的核心问题，认知神经科学的最新进展表明额中线θ波是认知控制的一种机制。本研究在一项明确涉及认知控制的Go/No-go任务中，检测了海洛因依赖患者的额中线θ波缺陷。在等概率Go/No-go任务期间，从15名男性海洛因成瘾者和17名人口统计学匹配的健康对照者中收集脑电图读数。研究结果显示，与健康对照者相比，海洛因成瘾者对Go刺激的反应明显更慢。海洛因成瘾者在Go和No-go条件之间的额中线θ波调制也较少。这些发现为理解与药物成瘾相关的认知功能障碍的本质提供了进一步的证据。
