小胶质细胞在脊髓损伤中的作用。
Role of microglia in spinal cord injury.
机构信息
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States; Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI, United States.
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States; Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI, United States.
出版信息
Neurosci Lett. 2019 Sep 14;709:134370. doi: 10.1016/j.neulet.2019.134370. Epub 2019 Jul 5.
Myeloid cells are important effector cells in the injured spinal cord tissue. Microglia and monocyte-derived macrophages serve important functions in the injured spinal cord, and their distinctive roles can now be studied more efficiently with the help of reporter mice and cell specific markers that were described in recent years. Focusing on microglia, this review discusses the microglial response to injury, microglia specific effects and the interaction between microglia and other cell types in the injured spinal cord.
髓系细胞是损伤脊髓组织中的重要效应细胞。小胶质细胞和单核细胞衍生的巨噬细胞在损伤的脊髓中发挥重要作用，近年来借助报告小鼠和细胞特异性标志物，它们的独特作用能够得到更有效的研究。本文聚焦小胶质细胞，讨论了小胶质细胞对损伤的反应、小胶质细胞的特异性作用以及小胶质细胞与损伤脊髓中其他细胞类型的相互作用。
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