Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, 1650 Cedar Ave., Montreal, Quebec H3G 1A4, Canada.
Clement J. Zablocki Veterans Affairs Medical Center, Department of Neurosurgery, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI 53226, United States.
J Neuroimmunol. 2018 Aug 15;321:97-108. doi: 10.1016/j.jneuroim.2018.06.003. Epub 2018 Jun 6.
The past decade has revealed much about the complexity of the local inflammatory response after spinal cord injury (SCI). A major challenge is to distinguish between microglia and monocyte-derived macrophages (MDMs) to determine their phenotype and function. Transcriptome studies have revealed microglia-selective genes but are still limited in scope because many markers are downregulated after injury. Additionally, new genetic reporter mice are available to study microglia and MDMs. There is more evidence now for the plasticity and heterogeneity of microglia and MDMs. We also discuss the role of neutrophils that are the first peripheral cells to enter the injured CNS.
过去十年揭示了许多有关脊髓损伤 (SCI) 后局部炎症反应的复杂性。主要挑战是区分小胶质细胞和单核细胞衍生的巨噬细胞 (MDM)，以确定其表型和功能。转录组研究揭示了小胶质细胞选择性基因，但范围仍然有限，因为许多标记在损伤后下调。此外，现在有新的遗传报告小鼠可用于研究小胶质细胞和 MDM。现在有更多证据表明小胶质细胞和 MDM 的可塑性和异质性。我们还讨论了中性粒细胞的作用，中性粒细胞是第一批进入受损中枢神经系统的外周细胞。
