大肠杆菌K93和K53荚膜多糖的结构研究。

Structural studies of the Escherichia coli K93 and K53 capsular polysaccharides.

作者信息

Bax A, Summers M F, Egan W, Guirgis N, Schneerson R, Robbins J B, Orskov F, Orskov I, Vann W F

机构信息

Laboratory of Chemical Physics, National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, Maryland 20892.

出版信息

Carbohydr Res. 1988 Feb 15;173(1):53-64. doi: 10.1016/s0008-6215(00)90802-4.

DOI:10.1016/s0008-6215(00)90802-4

PMID:3128402

Abstract

The structures of the Escherichia coli K93 and K53 capsular polysaccharides have been investigated by chemical and spectroscopic methods. The repeating unit of both polymers was found to be----3)-beta-D-Galf-(1----f)-beta-D-GlcAp-(1. The O-5 and O-6 atoms of D-galactose are acetylated in the repeating unit of the K93 polymer, but only O-2 is acetylated in the K53 polymer. The K93 polysaccharide is cross-reactive with the Neisseria meningitidis Group A capsular polysaccharide (of known structure). The K53 polysaccharide, although structurally similar to that from K93 organisms, does not cross-react with the Group A polymer.

摘要

已通过化学和光谱方法研究了大肠杆菌K93和K53荚膜多糖的结构。发现这两种聚合物的重复单元均为----3)-β-D-半乳糖基-(1----f)-β-D-葡萄糖醛酸-(1。在K93聚合物的重复单元中，D-半乳糖的O-5和O-6原子被乙酰化，但在K53聚合物中只有O-2被乙酰化。K93多糖与已知结构的A群脑膜炎奈瑟菌荚膜多糖有交叉反应。K53多糖虽然在结构上与K93菌株的多糖相似，但与A群聚合物无交叉反应。