Department of Food Science, National Taiwan Ocean University, Keelung City, Taiwan.
Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung City, Taiwan.
Toxicol Lett. 2019 Oct 10;314:75-81. doi: 10.1016/j.toxlet.2019.07.006. Epub 2019 Jul 5.
Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety. Peanuts and peanut products are the major sources of aflatoxin exposure. Therefore, some reduction interventions have been developed to minimize contamination throughout the peanut production chain. The purpose of this study is to estimate the efficacy of interventions in reducing the health impact of hepatocellular carcinoma caused by aflatoxin contamination in peanuts. The estimated total Disability-Adjusted Life Years (DALYs) were calculated using FDA-iRISK software. Six aflatoxin reduction strategies were evaluated, including good agricultural practice (GAP), biocontrol, Purdue Improved Crop Storage packaging, basic processing, ozonolysis, and ultraviolet irradiation. The results indicated that basic processing could prevent huge public health loss of 4,079.7-21,833 total DALYs per year. In addition, GAP and biocontrol were both found to be effective strategies in the farm field. Meanwhile, the other three interventions had limited effectiveness in reducing total DALYs. In conclusion, this study could help farmers, processing plants, and government policy makers to alleviate aflatoxin contamination issues in the peanut production chain.
黄曲霉毒素是一种毒性很高的真菌次生代谢物，能够污染各种类型的粮食作物。国际癌症研究机构已将其确定为人类 1 类致癌物。慢性黄曲霉毒素暴露已成为全球关注的公共食品安全问题。花生及其制品是黄曲霉毒素暴露的主要来源。因此，已经开发了一些减少干预措施，以最大限度地减少花生生产链中的污染。本研究旨在估计干预措施在减少花生黄曲霉毒素污染对肝细胞癌健康影响方面的效果。使用 FDA-iRISK 软件计算了估计的总伤残调整生命年（DALYs）。评估了六种黄曲霉毒素减少策略，包括良好农业规范（GAP）、生物防治、普渡改进作物储存包装、基本加工、臭氧化和紫外线照射。结果表明，基本加工每年可预防 4079.7-21833 总 DALYs 的巨大公共卫生损失。此外，在农田中发现 GAP 和生物防治都是有效的策略。同时，其他三种干预措施在减少总 DALYs 方面效果有限。总之，本研究可以帮助农民、加工厂和政府决策者缓解花生生产链中的黄曲霉毒素污染问题。
