Department of Child and Adolescent Health, School of Public Health, Bengbu Medical College, Bengbu, PR China.
Royal Adelaide Hospital, Adelaide, Australia.
Early Hum Dev. 2019 Sep;136:14-20. doi: 10.1016/j.earlhumdev.2019.07.005. Epub 2019 Jul 5.
The aim of this study was to analyze the relationship between 2D:4D and childhood overweight or obesity, which might indirectly show the role of prenatal hormone in childhood overweight or obesity.
Using stratified cluster sampling approach, a school-based cross-sectional investigation was undertaken among 687 children and adolescents aged 8-15 years. Each participant's index finger (2D) and ring finger (4D) length, height, weight, testosterone, and estradiol levels were measured, and their dietary behaviors, physical and sedentary activities were also surveyed.
The prevalence of overweight or obesity among children and adolescents aged 8- and 12-15 years was 36.0% and 25.9%, respectively (P < 0.05). There were no associations between 2D:4D and overweight or obesity in both boys and girls (P > 0.05). However, 2D and multiplying index of digit ratio and length (MIDRL) associated directly with overweight or obesity among boys (OR (95%CI) were 1.45 (1.00, 2.14), 1.46 (1.01, 2.11), respectively), and was indirectly related to overweight or obesity by testosterone (OR were 1.30, 1.26, respectively).
In boys, 2D and MIDRL were directly related to overweight or obesity, and indirectly associated with overweight or obesity by testosterone, which suggested that prenatal hormone exposure might associate with overweight or obesity among boys.
本研究旨在分析 2D:4D 与儿童超重或肥胖之间的关系，这可能间接表明产前激素在儿童超重或肥胖中的作用。
采用分层整群抽样方法，对 687 名 8-15 岁的儿童和青少年进行了一项基于学校的横断面调查。测量了每位参与者的食指（2D）和无名指（4D）长度、身高、体重、睾酮和雌二醇水平，并调查了他们的饮食行为、身体活动和久坐行为。
8 岁和 12-15 岁儿童和青少年超重或肥胖的患病率分别为 36.0%和 25.9%（P<0.05）。在男孩和女孩中，2D:4D 与超重或肥胖均无相关性（P>0.05）。然而，2D 和指长比指数（MIDRL）与男孩的超重或肥胖直接相关（OR（95%CI）分别为 1.45（1.00，2.14）和 1.46（1.01，2.11）），并通过睾酮间接与超重或肥胖相关（OR 分别为 1.30 和 1.26）。
在男孩中，2D 和 MIDRL 与超重或肥胖直接相关，通过睾酮与超重或肥胖间接相关，这表明产前激素暴露可能与男孩超重或肥胖有关。
