一组哥伦比亚儿童中与非综合征性唇腭裂相关的恒牙牙列异常

Dental Anomalies in Permanent Teeth Associated With Nonsyndromic Cleft Lip and Palate in a Group of Colombian Children.

作者信息

Yezioro-Rubinsky Salomón, Eslava-Schmalbach Javier H, Otero Liliana, Rodríguez-Aguirre Sara A, Duque Ángela M, Campos Flora M, Gómez Juan P, Gómez-Arango Sara, Posso-Moreno Sandra L, Rojas Nancy E, Garzón-Orjuela Nathaly

机构信息

Faculty of Dentistry, Universidad Nacional de Colombia, Bogotá, Colombia.

Hospital Universitario Nacional de Colombia. School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.

出版信息

Cleft Palate Craniofac J. 2020 Jan;57(1):73-79. doi: 10.1177/1055665619861498. Epub 2019 Jul 8.

DOI:10.1177/1055665619861498

PMID:31284730

Abstract

OBJECTIVES

To assess the risk of dental anomaly presentation in permanent teeth in a group of Colombian children with nonsyndromic cleft lip and palate (NSCLP) and to determine the frequency of the anomalies according to the cleft type.

METHODS

An analytical matched case-control study was conducted with 210 controls and 210 patients with NSCLP. The patients were classified into 3 groups: complete right unilateral cleft lip and palate (RCLP), complete left unilateral cleft lip and palate (LCLP), and complete bilateral cleft lip and palate (BCLP). Univariate and multivariate Poisson regression models were used to analyze paired samples (Bonferroni adjustment, ≤ .002).

RESULTS

A high risk of finding agenesis of the maxillary lateral incisors, supernumerary teeth, microdontia of the maxillary lateral incisors, and rotation of the maxillary central incisors adjacent to the cleft ( < .0001) was observed in the patients with NSCLP. One or more dental anomalies were found in 98% of patients with BCLP, in 96% of those with LCLP, and in 87% of those with RCLP. Most of the anomalies were located on the cleft area. The incidence relative risk (IRR) of anomalies was highest in patients with BCLP (IRR: 10.5; 95% confidence interval [CI]: 6.76-16.3), followed by in those with LCLP (IRR: 8.51; 95% CI: 5.64-12.8).

CONCLUSIONS

Most dental anomalies were found in the cleft area; this was expected because the cleft area was the most affected in the patients included in this study.

摘要

目的

评估一组患有非综合征性唇腭裂（NSCLP）的哥伦比亚儿童恒牙出现牙齿异常的风险，并根据腭裂类型确定异常的频率。

方法

进行了一项分析性配对病例对照研究，有210名对照者和210名NSCLP患者。患者被分为3组：完全性右侧单侧唇腭裂（RCLP）、完全性左侧单侧唇腭裂（LCLP）和完全性双侧唇腭裂（BCLP）。使用单变量和多变量泊松回归模型分析配对样本（Bonferroni校正，P≤0.002）。

结果

在NSCLP患者中观察到上颌侧切牙缺失、多生牙、上颌侧切牙过小牙以及腭裂旁上颌中切牙旋转的高风险（P<0.0001）。在98%的BCLP患者、96%的LCLP患者和87%的RCLP患者中发现了一种或多种牙齿异常。大多数异常位于腭裂区域。异常的发病率相对风险（IRR）在BCLP患者中最高（IRR：10.5；95%置信区间[CI]：6.76 - 16.3），其次是LCLP患者（IRR：8.51；95%CI：5.64 - 12.8）。