Laboratory of Cancer Chemoprevention and Oncopharmacology, N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, Russian Federation.
International Research Centre "Biotechnologies of the Third Millennium", ITMO University, St. Petersburg, Russian Federation.
Anticancer Agents Med Chem. 2019;19(13):1627-1632. doi: 10.2174/1871520619666190705143927.
There is some evidence that Benign Prostatic Hyperplasia (BPH) may increase the risk of developing prostate cancer, so conducting research on effective BPH inhibitors is important.
This research studied the inhibitory effect of Iodized Serum Milk Protein (ISMP) on BPH in rats. ISMP is a concentrate of lactic protein containing 2.2% iodine.
Male Wistar rats, aged 18 months, were used. In the intact control group, sunflower oil was administered intragastrically by gavage. In 36 rats, BPH was induced by surgical castration, followed by subcutaneous injections of prolonged testosterone - omnadren, 25mg/kg every other day (7 administrations). One group of rats served as BPH-control. ISMP and finasteride (positive control), dissolved in sunflower oil, were administered to rats intragastrically daily at a dose of 200μg/kg and 5mg/kg, respectively, for 4 weeks starting immediately after castration.
ISMP inhibited the development of BPH in rats, significantly reducing the mass of the prostate and its parts (except for the anterior lobes) by 1.1-1.3 times and the prostatic index (the ratio of prostate weight to the body weight) - by 1.3-1.4 times. Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP. Histological analysis of the prostate showed fewer pronounced morphological hyperplasia signs in animals treated with ISMP or finasteride.
The iodine-containing preparation ISMP has the ability to inhibit the development of BPH in rats although its activity is somewhat lower than that of finasteride.
有证据表明良性前列腺增生（BPH）可能会增加前列腺癌的发病风险，因此研究有效的 BPH 抑制剂很重要。
本研究旨在研究碘血清乳蛋白（ISMP）对大鼠 BPH 的抑制作用。ISMP 是一种含碘 2.2%的乳蛋白浓缩物。
使用 18 个月龄雄性 Wistar 大鼠。在完整对照组中，通过灌胃给予葵花籽油。在 36 只大鼠中，通过手术去势诱导 BPH，然后皮下注射长效睾酮-omnadren，每两天 25mg/kg（共 7 次）。一组大鼠作为 BPH 对照组。ISMP 和非那雄胺（阳性对照）溶解在葵花籽油中，分别以 200μg/kg 和 5mg/kg 的剂量每天灌胃给药，从去势后立即开始，持续 4 周。
ISMP 抑制了大鼠 BPH 的发展，使前列腺及其各部分（除前叶外）的质量分别减少 1.1-1.3 倍，前列腺指数（前列腺重量与体重的比值）减少 1.3-1.4 倍。非那雄胺抑制了 BPH 的发展，其活性比 ISMP 更高（1.1-1.3 倍）。前列腺组织学分析显示，用 ISMP 或非那雄胺治疗的动物中，形态学增生迹象较少。
含碘制剂 ISMP 具有抑制大鼠 BPH 发展的能力，尽管其活性略低于非那雄胺。
