抗生素管理在促进合理使用抗生素中的作用。
The Role of Antibiotic Stewardship in Promoting Appropriate Antibiotic Use.
作者信息
Ha David R, Haste Nina M, Gluckstein Daniel P
机构信息
Keck Graduate Institute School of Pharmacy, Pomona Valley Hospital Medical Center, Claremont, California (DRH).
University of California San Diego Health and University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, California (NMH).
出版信息
Am J Lifestyle Med. 2017 Apr 4;13(4):376-383. doi: 10.1177/1559827617700824. eCollection 2019 Jul-Aug.
Antibiotics are one of the most significant medical discoveries in human history. The widespread use of antibiotics has resulted in the emergence of antibiotic-resistant pathogens. This fact, coupled with the paucity of new antibiotic developments, has spurred efforts to combat antibiotic resistance. One of the most critical components of these efforts is antibiotic stewardship, a multidisciplinary endeavor, employing a collection of interventions in a variety of health care settings with the aim of promoting appropriate utilization of antibiotics. This article describes antibiotic stewardship programs and key practices used to minimize the development and spread of antibiotic-resistant pathogens including the optimization of antibiotic pharmacokinetics and pharmacodynamics, the application of rapid diagnostic tools, and the use of computerized provider order entry tools.
抗生素是人类历史上最重要的医学发现之一。抗生素的广泛使用导致了耐药病原体的出现。这一事实，再加上新抗生素研发的匮乏，促使人们努力对抗抗生素耐药性。这些努力中最关键的组成部分之一是抗生素管理，这是一项多学科的工作，在各种医疗环境中采用一系列干预措施，旨在促进抗生素的合理使用。本文介绍了抗生素管理计划以及用于尽量减少耐药病原体的产生和传播的关键做法，包括优化抗生素药代动力学和药效学、应用快速诊断工具以及使用计算机化医嘱录入工具。
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