微小RNA-138在人类癌症中的关键作用。
Pivotal role of microRNA-138 in human cancers.
作者信息
Yeh Margaret, Oh Christina S, Yoo Ji Young, Kaur Balveen, Lee Tae Jin
机构信息
Department of Neurosurgery, University of Texas Health Science Center at Houston, McGovern Medical School Houston, TX 77030, USA.
Biochemistry and Cell Biology, Department of Biosciences, Rice University Houston, TX 77030, USA.
出版信息
Am J Cancer Res. 2019 Jun 1;9(6):1118-1126. eCollection 2019.
Aberrant expression of certain microRNAs (miRNAs) has been implicated in cancers as a promising druggable target due to the fact that a modulation of the deregulated single miRNA seems to revert the therapeutically unfavorable gene expressions in cancer cell by targeting multiple genes. Global miRNA profiling from a number of patient cohorts in various type of human cancers has identified miR-138 as a signature of tumor suppressor that are down-regulated in most types of human cancer. As a tumor suppressor, miR-138 can inhibit oncogenic proteins by directly bind to their mRNAs. However, in rare cases of cancer stem cell population from glioblastoma, miR-138 seems to be down-regulated and plays an oncogenic function. This review will summarize accumulating evidence that has shown the expression and functional role of miR-138 in various human cancers with its target genes and pathways in a hope to find a better therapeutic option to treat human cancers.
某些微小RNA（miRNA）的异常表达与癌症有关，由于调控单个失调的miRNA似乎可以通过靶向多个基因来逆转癌细胞中对治疗不利的基因表达，因此它是一个有前景的可成药靶点。来自多个不同类型人类癌症患者队列的全基因组miRNA分析已将miR-138鉴定为肿瘤抑制因子的标志，其在大多数类型的人类癌症中表达下调。作为一种肿瘤抑制因子，miR-138可以通过直接与其mRNA结合来抑制致癌蛋白。然而，在胶质母细胞瘤的罕见癌症干细胞群体中，miR-138似乎表达下调并发挥致癌作用。本综述将总结越来越多的证据，这些证据表明了miR-138在各种人类癌症中的表达、功能作用及其靶基因和信号通路，以期找到更好的治疗人类癌症的选择。
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