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头颈部癌症游离组织移植的争议:文献回顾。

Controversies in free tissue transfer for head and neck cancer: A review of the literature.

机构信息

University of Miami, Miller School of Medicine, Miami, Florida.

出版信息

Head Neck. 2019 Sep;41(9):3457-3463. doi: 10.1002/hed.25853. Epub 2019 Jul 9.

DOI:10.1002/hed.25853
PMID:31286627
Abstract

BACKGROUND

Microvascular free tissue transfer provides superior functional outcomes when reconstructing head and neck cancer defects. Careful patient selection and surgical planning is necessary to ensure success, as many preoperative, intraoperative, and postoperative patient and technical factors may affect outcome.

AIMS

To provide a concise, yet thorough, review of the current literature regarding free flap patient selection and management for the patient with head and neck.

MATERIALS AND METHODS

PubMed and Cochrane databases were queried for publications pertaining to free tissue transfer management and outcomes.

RESULTS

Malnutrition and tobacco use are modifiable patient factors that negatively impact surgical outcomes. The use of postoperative antiplatelet medications and perioperative antibiotics for greater than 24 hours have not been shown to improve outcomes, although the use of clindamycin alone has been shown to have a higher risk of flap failure. Liberal blood transfusion should be avoided due to higher risk of wound infection and medical complications.

DISCUSSION

There is a wide range of beliefs regarding proper management of patients undergoing free tissue transfer. While there is some data to support these practices, much of the data is conflicting and common practices are often continued out of habit or dogma.

CONCLUSION

Free flap reconstruction remains a highly successful surgery overall despite as many different approaches to patient care as there are free flap surgeons. Close patient monitoring remains a cornerstone of surgical success.

摘要

背景

游离组织移植在头颈部癌症缺损重建中提供了更好的功能结果。为了确保成功,需要仔细选择患者并进行手术规划,因为许多术前、术中、术后的患者和技术因素可能会影响结果。

目的

提供关于头颈部游离皮瓣患者选择和管理的当前文献的简洁而全面的综述。

材料和方法

在 PubMed 和 Cochrane 数据库中查询了有关游离组织转移管理和结果的出版物。

结果

营养不良和吸烟是可改变的患者因素,会对手术结果产生负面影响。虽然单独使用克林霉素已被证明有更高的皮瓣失败风险,但术后使用抗血小板药物和超过 24 小时的围手术期抗生素并未显示出改善结果。由于更高的伤口感染和医疗并发症风险,应避免自由输血。

讨论

对于接受游离组织转移的患者的适当管理,存在广泛的信念。虽然有一些数据支持这些做法,但许多数据是相互矛盾的,常见的做法往往是出于习惯或教条。

结论

尽管有许多不同的游离皮瓣外科医生的方法,但游离皮瓣重建总体上仍然是一种非常成功的手术。密切监测患者仍然是手术成功的基石。

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